He might cry a lot. Deku is very emotional, and being cheated on would be a very painful experience for him. He could also get angry, which is rare for him, but this situation would be so unjust that he might not be able to hold it in. He'd probably start to question his self - worth too, thinking that there was something wrong with him that made his partner cheat.
One possible plot could be Deku finding out his partner cheating through overhearing a conversation. He might be heartbroken and initially go into denial.
Some characters might try to understand Deku's motives. Kirishima, who was close to Bakugou, would be angry at first but might also try to find out if there were any extenuating circumstances. However, many would be afraid of Deku, seeing him as a threat now that he has killed one of their own.
All Might is another character that is very likely to appear. As Deku's mentor, he has a big influence on him. He would be concerned about Deku's health in relation to his quirk. Recovery Girl, the school nurse, would also be an important character. She would be the one trying to diagnose and treat Deku's illness.
One likely antagonist could be a powerful new villain who has the ability to mind - control. This villain might target Deku specifically because of his potential as a hero. Another could be an old enemy of the hero society who sees Deku as a key to their revenge.
His friends would be really shocked at first. Uraraka might be the first to try and comfort him, seeing as she has a kind heart. Bakugo, on the other hand, would probably be both confused and a bit angry at the situation. All - Might would likely feel a sense of responsibility to protect Deku even more than before. The teachers at UA would probably start researching how to reverse the transformation immediately.
Deku might be completely shocked at first. Since Bakugou has always been so aggressive towards him, he would never expect such a confession. He might just stand there, mouth agape, not knowing what to say.
Deku might be initially shocked. He's used to Bakugou's aggression, but an actual injury is different. He could be in pain and disbelief at first. Then, he might try to downplay it, especially if he doesn't want to cause trouble for Bakugou, because Deku is generally a very forgiving character.
In fanfiction, if Deku gets kidnapped, his friends from U.A. High would likely launch a rescue mission. Bakugo might be especially determined, as much as he tries to hide his concern. They would use their quirks in creative ways to track Deku down.
Bakugo would likely be furious. He'd feel betrayed and would probably be the first to attack Deku, yelling at him about how he's thrown away everything they've worked for. Uraraka might be more empathetic. She'd try to understand what drove Deku to become a villain and hope there's a way to bring him back to the side of good.
Uraraka would be heartbroken. She was one of Deku's closest friends. She might lose some of her usual cheerfulness and become more focused on finding out who or what was responsible for his death. She could also struggle with her own self - confidence in using her quirk, as Deku was always an inspiration to her.