If Tsukune has a romantic interest, that relationship would be put to the test. His partner might be hesitant to be with him now that he's a vampire. There could be a lot of drama as they try to figure out if their relationship can still work. On the other hand, he might also attract the attention of vampire suitors, which would create jealousy and conflict in his love life.
His relationship with his human friends would definitely change. They might be scared of him at first, especially if he shows signs of his new vampire nature like a craving for blood. Some friends might try to distance themselves from him, while others might be more understanding and try to help him control his new urges.
His relationship with Sakura would be very different. Instead of the old friendship/romantic tension, Sakura might be initially afraid of him as a vampire. She would have to overcome her fear and see that Naruto is still the same person inside. His relationship with Sasuke could also be strained. Sasuke might see Naruto's transformation as a sign of weakness or a new threat.
His relationship with Mika would be very different. Since Mika is already a vampire, they might have a new understanding of each other. However, there could also be some jealousy or power struggle as Yuu adjusts to his new vampire status. With his human friends, like Shinoa and the others, they might be initially afraid of him. But Yuu would probably try his best to show them that he's still the same person who wants to protect them.
His relationship with Sasuke would be really interesting. Since Sasuke has his own complex connection to the Uchiha clan and Madara, Naruto becoming a Madara fan could either bring them closer together in understanding the Uchiha's past or drive them further apart if Sasuke doesn't agree with Naruto's new - found admiration. Maybe Naruto would start to push Sasuke towards a more 'Madara - like' view of power and revenge.
His relationship with Sakura would change a lot. Sakura might be initially scared of Naruto's fox form, but as she realizes it's still him inside, she would start to see him in a new light. She could become more protective of him. With Kakashi, Kakashi would be more cautious and observant, trying to figure out how to help Naruto control his new form. And with his rivals, they might either be more envious or more afraid of him now that he has this unique transformation.
His relationship with Sasuke would be very different. Sasuke might see Naruto as even more of an enigma. He could be both jealous of Naruto's new power and also concerned about what Naruto has become. Naruto, on the other hand, would try to show Sasuke that he's still the same person deep down.
Naruto's relationship with the villagers could be affected. As he becomes a Minato fan, he would try to uphold Minato's legacy even more. The villagers, seeing Naruto's newfound admiration for Minato, might start to see Naruto in a new light, more like how they saw Minato. Also, his relationship with Hinata could be different. Naruto might start to model his family - centered values after Minato, which could bring him and Hinata even closer as they plan their own family.
His relationships would change drastically. With his friends in the Hidden Leaf, there would be a sense of distance. For example, Sasuke might be confused by Naruto's decision. But at the same time, Naruto might form new relationships with the animals and plants in his hermitage area.
His relationship with Sasuke would become very strained. Sasuke, who has always been somewhat distrustful, would see Naruto as a real threat now. He might even consider Naruto an enemy and try to stop him.
Naruto's relationship with the other Leaf Village ninjas would also shift. Some might be suspicious of his new - found admiration for Itachi, especially those who were directly or indirectly affected by Itachi's actions. However, others who understand Itachi's true motives, like Kakashi, might support Naruto. This could create a complex web of relationships within the village, with Naruto at the center trying to balance his new beliefs and his old friendships.
His relationship with Sasuke would be severely strained. Sasuke, who has his own goals and views on power, would see Naruto's demon transformation as either a threat or a sign of weakness. He might distance himself from Naruto or even see him as an enemy to be defeated.