In a 'naruto runs a shop' fanfiction, he could run a pet shop. Naruto has always had a connection with animals. He rescues and rehabilitates injured animals and then finds them new homes through his shop. He might also have some special ninja - animal hybrids in his shop that are a big draw for customers.
Well, Naruto might sell ramen in his shop. After all, he loves ramen so much. He could have his friends like Sasuke and Sakura helping out sometimes. Maybe there would be special ninja - themed items for sale too.
His ninja friends like Sasuke, Sakura, and Kakashi would surely be regulars. Sasuke might come to buy things secretly to support Naruto's business. Sakura could be there to get supplies for her medical ninja work if it's a general store. And Kakashi would stop by for a chat and to pick up some new reading material if Naruto sold books.
In this fanfiction, Naruto could also face challenges in running the clinic. He might struggle with administrative tasks since he's used to the action - packed ninja life. But he could hire some of his ninja friends to help, like Sakura as a medical expert and Rock Lee to handle the physical tasks around the clinic.
In this fanfiction, Naruto might run away to Iwa because he feels misunderstood in Konoha. Maybe he discovers some secrets related to his family that make him think Iwa has the answers. He could face many challenges on his way there, like avoiding capture by Konoha ninjas who think he's a traitor.
One possible plot could be that Naruto and Sasuke run away to find a place where they can train without the interference of the Hidden Villages. They might be on a quest to become stronger together, away from the prying eyes of their respective villages which have different expectations of them.
It could be that a prophecy or a false accusation is made against Naruto, saying he will bring destruction to the village. Hinata doesn't believe it for a second. Instead of waiting for the village to turn on Naruto, she convinces him to run away with her. They then travel to other villages, learning different jutsu and cultures, all while trying to clear Naruto's name.
One possible plot could be that Naruto runs away to Suna to escape some sort of danger in Konoha. Maybe there's a powerful enemy after him and he thinks Suna can offer him protection. He could also be running away from some internal conflict within Konoha, like issues with the villagers not fully accepting him still.
Well, it could be that Naruto, using his ninja skills and knowledge, takes over the criminal underworld to reform it. Maybe he uses his powerful jutsus to intimidate the bad guys into following his new rules.
One possible plot could be that a new and mysterious ingredient is discovered in the Naruto world. This ingredient is added to the ramen in the shop, and it gives those who eat it special powers. Naruto and his friends then have to protect the ingredient from villains who want to use it for evil.
In a 'naruto runs away fanfic', one possible plot could be that Naruto runs away after feeling misunderstood by the village. He might go on a journey to find a place where he can truly belong. Along the way, he could meet new allies or enemies. For example, he might encounter a group of outcasts who are also on the run from different villages. They could team up and form a sort of 'runaway family' where Naruto learns new skills and perspectives outside of the Hidden Leaf's teachings.