Sasuke might be confused at first. Since he has his own complex relationship with his family, Naruto's situation could make him re - evaluate things. He may try to talk to Naruto to understand his reasons, or he could be distant, thinking Naruto is overreacting.
Iruka - sensei would be very concerned. He has always been like a father figure to Naruto. He would probably try to mediate and help Naruto see the good in his parents. He might tell Naruto stories of how his parents sacrificed for the village and for him, hoping to change Naruto's mind.
The plot could also develop into a conflict with the village. Since Naruto is a key figure in the village, his rejection of his family might have political implications. The village elders might try to interfere and bring Naruto back to the 'right path' which could lead to a power struggle between Naruto and the village leadership.
His relationship with Sasuke could be affected in a big way. Sasuke is very much tied to his clan, and Naruto's rejection might make Sasuke view him differently. It could either create a rift between them or make Sasuke question his own loyalty to his clan. As for his friends like Sakura, she might be initially shocked but then try to understand Naruto's perspective.
His relationship with Sasuke would likely become even more strained. Since they already have a complex relationship, Naruto's distance would make Sasuke wonder what's wrong. Sasuke might initially think Naruto is giving up on their bond or on him, which could lead to more misunderstandings.
It has a huge impact. Naruto grows up lonely and ostracized. This abandonment by his parents means he has to create his own family in a sense. He forms strong bonds with his friends like Sasuke and Sakura. His character develops a sense of resilience. He doesn't let the fact that he was left behind break him. Instead, he uses it as fuel to become stronger, both physically and emotionally. He wants to show that even without his parents, he can be someone great.
For Sasuke, Naruto's departure could be a wake - up call. He might realize how much Naruto actually meant to him and the village. It could make him re - evaluate his own goals and actions, perhaps leading him to try and find Naruto to bring him back.
Naruto might become more distrustful. Being kidnapped from his parents at a young age could make him question the intentions of others. He may grow up being more cautious around people and not easily trust those who seem friendly at first sight.
His relationship with Sasuke could become more complex. Sasuke, who has his own history of leaving the village, might view Naruto's departure in different ways. He could either see it as a sign of weakness or as a new opportunity for them to both be on the outside and understand each other better.
Naruto's exile would also change his relationship with the villagers. Those who once supported him might turn their backs, while some might secretly hope for his return. And for the new generation of ninja in Konoha, Naruto could become a symbol of the village's wrongdoings, or a hero who was wrongly exiled, depending on how the story is written.
It could be that in this fanfiction, there are some external influences like an enemy who has manipulated Naruto's mind. The enemy might have planted false memories or ideas in Naruto's head, making him believe that his parents are not who he thought they were, leading to his rejection.
It's a major turning point. Firstly, it creates a deep - seated loneliness in Naruto. He grows up without the love and guidance of his parents, which makes him seek approval in rather boisterous ways. He's always trying to show the village that he's someone worthy. This experience also hardens him in a way. He has to face the cruel reality of life from a very early stage, and that toughens his mental state, making him more resilient in the face of difficulties.