Well, with his village mates, some might support his decision. Those who also feel restricted by their clans might see Naruto as a symbol of breaking free. However, there will be others who will be against it. The elders of the village who value the clan system may see Naruto as a troublemaker. His relationship with his mentors could also change. Kakashi, for example, might try to guide Naruto through this difficult choice, but at the same time be concerned about the implications it has for the village's stability.
His relationship with Sasuke could be affected in a big way. Sasuke is very much tied to his clan, and Naruto's rejection might make Sasuke view him differently. It could either create a rift between them or make Sasuke question his own loyalty to his clan. As for his friends like Sakura, she might be initially shocked but then try to understand Naruto's perspective.
It could also affect his friendships. Some friends might try to convince him to let go of his hatred, which could cause friction. On the other hand, some friends might support his stance, which could lead to them being at odds with the clan. For example, Sasuke, who has his own issues with his clan, might react in different ways depending on Naruto's situation.
It would also impact his relationship with his village. The village has always seen Naruto as a part of their heritage in a way, especially considering his connection to the Fourth Hokage. If he rejects his heritage, some villagers might feel betrayed or confused.
Some friends might feel betrayed. If they are very clan - oriented, they could see Naruto's leaving as a sign that he doesn't value the clan and by extension, their friendship. However, his true friends like Sasuke or Sakura might understand his reasons. Sasuke, who has his own issues with his clan, might be more empathetic. Sakura, who has seen Naruto's determination, could support his decision in the long run.
His relationship with clan members might become strained. They may side with their clan heads, causing Naruto to be at odds with them even if he was friends with some of them before. For instance, if a clan member is loyal to their head's views that Naruto opposes.
In this fanfiction, Naruto could reject his clan because of the dark secrets or past actions of the clan. He is a character who values justice and friendship. If the clan has a history of wrongdoings that he discovers, he may not want to be associated with it. Also, Naruto has his own dreams and goals that might not fit within the framework of the clan. He has always been a bit of a rebel, and rejecting the clan could be his way of standing up for what he believes in.
Well, in some fanfictions, Naruto might start by finding suitable partners within the village. Since he is the last of his clan, he could look for women who are willing to carry on the Uzumaki bloodline. He may also use his influence as a hero to encourage others to support his clan - revival efforts, like getting the village to provide resources for the new Uzumaki generation.
In some fanfictions, Naruto might restore his clan by using a powerful jutsu to bring back the dead members. For example, a fictional super - level resurrection jutsu could be discovered. However, this would likely have many consequences and moral implications within the Naruto universe.
His relationship with his sensei, like Kakashi, could become more complex. Kakashi would feel guilty for not being able to protect Naruto from the experiments. And Naruto might start to question Kakashi's ability to keep him safe. This could lead to a strain in their relationship at first, but later they could grow closer as Kakashi helps Naruto recover from the trauma of the experiments.
If Naruto has a physical disability like a broken arm that doesn't heal properly in fanfiction, his friends like Sasuke and Sakura would need to step in and help him more. Sasuke might be more protective, which could change their dynamic from a competitive one to a more collaborative one. Sakura could use her medical skills to try and find a way to heal him, which would bring them closer. His relationship with his teachers, like Kakashi, would also change as they'd have to adjust their training methods.
His view of the world might change. Naruto is generally very positive, but being exiled by his own clan could make him more cynical. He might start to question the loyalty and fairness of family and clans in general. However, he could also use this experience to grow stronger and more empathetic towards others who are also ostracized.