Perhaps a forgotten or banished god could be the main antagonist. This god, filled with resentment for being cast out, could return with a vengeance and start causing chaos. He might be powerful enough that the only solution Percy sees is to slay him. This antagonist could bring in a lot of new lore and backstory to the fanfic as Percy uncovers the secrets of this god's past.
The Titan Kronos could also be a main antagonist in a different way. Even though he was defeated in the original series, what if he had a part of his essence that remained and found a way to possess a god? This possessed god would then act as Kronos' puppet, causing destruction, and Percy would have to figure out a way to slay the god - and ultimately Kronos' essence - to save the day.
Perhaps it could be a new evil force created as a result of Percy's sudden god - born existence. His new - found power could have unbalanced some ancient magic or prophecy, and this new evil entity rises to oppose him and restore the old balance. It might be a being made of dark magic that has a vendetta against Percy for disrupting the natural order of things.
A powerful Titan who wants to use Percy's newfound power as the God of Pain for his own evil purposes could be the main antagonist. This Titan might see Percy as a tool to spread chaos and destruction, and he tries to manipulate Percy into using his pain - based powers to harm innocents. Percy would then have to resist this Titan's influence and fight against him.
It could be an old enemy who now sees Percy as an even greater threat. Maybe Kronos' remnants. Since Percy is now a god, they might fear that he'll be able to fully destroy them. So they try to stop him from getting used to his powers or try to steal his powers.
Yes, in certain Percy Jackson fanfiction. Writers like to explore different aspects of his character and powers. Since Percy has such a strong connection to the demigod world and has faced numerous challenges involving gods, it's not a huge stretch in fanfiction for him to be portrayed as a God Slayer. This can add a whole new layer of drama and adventure to the story.
The main antagonist could be a powerful sorcerer who has found a way to enter the Percy Jackson game world. He has his own motives, perhaps he wants to steal the powers of the demigods for himself. He's able to manipulate the game's code to his advantage, creating illusions and false paths for Percy and his friends to follow. Or it could be an ancient spirit that was sealed away in the game but has been released. This spirit is angry at the gods and demigods and wants to destroy everything they hold dear. Also, a group of bandit demigods could be the main antagonists. They don't follow the rules of the game or the real - world demigod society and are causing chaos everywhere they go, trying to steal valuable items from both the game world and the real - world locations.
A powerful sorcerer from another realm who uses assassins as tools. This sorcerer could see Percy as a threat to their plans of taking over the demigod world. They send their best assassins after Percy and also try to manipulate other demigods against him. They are extremely cunning and have a vast array of dark magic at their disposal.
Nyx could be a great main antagonist. She's a primordial goddess of the night and Tartarus is her domain in a way. She might see Percy and his friends as intruders and try to stop them from leaving or achieving their goals. She could use her power over darkness and the unknown to create all sorts of obstacles for them.
The main antagonist could be a powerful Titan who wants to use Percy as a weapon to overthrow the Olympian gods. The Titan might see Percy's unique powers as a weapon as the perfect tool to gain ultimate power and reshape the world according to his own desires.
It could be a new, powerful Titan that has emerged from the depths of Tartarus. This Titan might be seeking revenge on the demigods for imprisoning the other Titans and sees Hylla and Percy as the biggest threats.
It could be an ancient and powerful Titan who was once in charge of fate but was overthrown. Now he wants to regain his power over fate and sees Percy as a threat. He might try to manipulate Percy into making bad decisions regarding fate.