Hermione's relationship with the wizarding community at large would be severely affected. The Ministry of Magic has certain views on Lycans, and she could be in danger of being hunted or restricted. Her friends from the Order of the Phoenix might be divided in their opinions. Some would see her as a liability, while others would see her as a victim who needs protection. Her relationship with the centaurs or other magical creatures could also change. They might view her as more of an equal now that she is a part - lycan, or they could see her as a threat to their territory or way of life.
Hermione's relationship with Harry and Ron would likely become more strained. They might be a bit afraid of her at first, not knowing how to deal with her new lycanthropy. However, as true friends, they would eventually try to understand and support her. With other Hogwarts students, she could face discrimination or fear from some, while others might be curious or sympathetic. Her relationship with teachers would also be different. Some, like Professor Snape, might use it as an excuse to be even harsher on her, while others, like Professor Lupin (who is also a werewolf), could be a source of guidance.
One possible plot could be that Hermione, as a Lycan, struggles to hide her identity within the Hogwarts community. Fleur, being perceptive, might notice something off about Hermione. Maybe Hermione is afraid of being discovered and ostracized, while Fleur, having her own experiences with being different (as a Veela), tries to help Hermione come to terms with her new lycanthropy. They could form a strong bond as they both deal with the challenges of being 'other' in the wizarding world.
Her relationship with the teachers would also shift. Professors like Flitwick might take a special interest in her as a Ravenclaw. He could give her extra - curricular projects related to advanced charms. And Snape might be a bit more begrudgingly respectful of her Ravenclaw intelligence, seeing her as a true academic rival in the making.
Hermione might develop a greater sense of adaptability. In a senary change situation, she would have to use her intelligence not just to understand new magic but also to quickly adjust to new social and cultural aspects within the magical world. Fleur, on the other hand, could become more humble. She may realize that her beauty and charm - based magic are not always enough and need to learn from Hermione's studious nature.
With Harry and Ron, they would become more protective of her. They'd have to learn to read her body language more carefully. For example, when she used to shout out answers in class, now she'd have to communicate her thoughts through gestures, and they'd have to be more attentive. And with Snape, he might initially think she was being disrespectful by not answering verbally, but then come to understand her situation and respect her even more for her determination to continue learning despite her handicap.
With Harry, their friendship could also shift. In the original, Hermione's Muggleborn status was part of her identity that Harry respected. If that changes, they might become closer in different ways. For example, if Hermione is from a powerful pure - blood family, she could use her family's resources to help Harry in his fight against Voldemort more directly. Their relationship could become more of a strategic alliance in addition to a friendship.
Romantically, if Hermione becomes a boy, she might attract different people. Maybe some of the female students who were just friends with her before start to have a crush on her. And she would have to figure out how to handle these new romantic interests while still being true to herself and her old friendships.
She might become more patient. Hufflepuff values loyalty and hard work, and Hermione would likely adapt to the patient and steady approach of Hufflepuff students. She may not be as quick - tempered when others don't understand things immediately.
Well, if Hermione has a crush on Fleur in the fanfiction, it could make things really interesting. For example, it might create some jealousy among her friends, especially if they don't understand her feelings. Ron might be really confused and a bit put off, since he has his own complicated relationship with Hermione. Harry, on the other hand, might be more understanding but still a bit surprised. And it could also change how Hermione approaches her studies and her role in the wizarding world. She might be more distracted, or she could be inspired to be more like Fleur in some ways, like being more confident in social situations.
Their relationship with Ron would be different. Instead of being in the same house, Ron would be in Gryffindor while they are in Ravenclaw. There might be a bit of an outsider feeling from Ron's side at first, but they would still be friends. However, their study and free - time activities would be more separated. For example, Ron might not be as involved in their Ravenclaw - centered projects.
Her relationship with Harry and Ron would be strained at first. They might feel betrayed or confused. But over time, if Hermione can show them that she's still the same person, they could reconcile. With the Slytherins, she might start off as an outcast but gradually earn their respect through her intelligence and determination.