Sakura could initially be shocked and then try to change herself. She might think that if she becomes more like what Sasuke wants, he won't find her annoying anymore. So she could start to be more reserved and less pushy in her interactions with him.
Sakura may also get angry. Despite her love for Sasuke, she has her own pride. Being called annoying could make her lash out at him, telling him that he's being unfair and that he doesn't really understand her intentions. She could then decide to distance herself from Sasuke for a while to prove that she doesn't need his approval and that she's strong on her own.
One possible reason could be that Sasuke is often brooding and focused on his revenge. Sakura's more open and sometimes pushy affection might seem annoying to him as he has no room for such distractions in his dark mindset.
She might be really hurt and start to question her self - worth. Maybe she becomes more withdrawn and less confident in herself.
Sakura would be over the moon. She would blush deeply and look at Sasuke with so much love in her eyes. She might be at a loss for words for a moment, but then she would find her voice and tell Sasuke that she has been waiting for this moment her whole life. She would also feel a sense of pride that Sasuke has chosen her, after all they have been through. And she would immediately start thinking about how to share the good news with their friends, especially Naruto, who has been like a brother to her and has also been a part of their journey.
Sakura might be initially frustrated. She's used to Sasuke being in control, so seeing him drunk could be a bit of a shock. But then she'd probably feel a sense of protectiveness and try to sober him up.
In some fanfictions, Sakura may be determined to find Sasuke and bring him back. She could set out on her own journey, facing various challenges along the way, and growing both as a person and as a ninja in the process of trying to reunite with him.
Sakura's reaction would depend on how the author writes her character development. If she's become more confident in herself, she might approach Sasuke with a more assertive attitude. She could tell him that she's not the same girl he left behind. However, she'd still have that underlying love for him. She might also be worried about how the village will accept Sasuke's return and how it will affect her standing in Konoha. So her reaction would be a complex blend of personal feelings and concerns for the village.
She could be heartbroken. Sakura has always loved Sasuke deeply, so his leaving for Naruto would be a huge blow to her. She might initially be in denial, not believing that Sasuke would choose Naruto over her.
Sakura might be heartbroken. She's been in love with Sasuke for so long. She could initially go into denial, thinking it's just a temporary thing. Then she might get angry and vow to prove herself to Sasuke, perhaps by becoming an even stronger ninja.
Sakura could also try to stand up for herself. If she believes that Sasuke is being unfair in his anger, she may argue back. For instance, if Sasuke is angry because of a misunderstanding, Sakura might try to clarify the situation and prove her point.
Sakura would probably be initially shocked and angry. She has always cared about Sasuke, and this betrayal would hit her hard. But she is also a strong - willed ninja. So, she would quickly gather her wits and start looking for ways to escape. She might try to use her knowledge of Sasuke's fighting style against him if she gets the chance.