Sakura might be initially frustrated. She's used to Sasuke being in control, so seeing him drunk could be a bit of a shock. But then she'd probably feel a sense of protectiveness and try to sober him up.
Sakura's reaction would be multi - faceted. At first, she might be taken aback as Sasuke is not one to let loose often. She would quickly shift into her medical ninja mode to make sure he hasn't poisoned himself with too much alcohol. Then, as she realizes he's just drunk, she would try to get him to a safe place. She might have mixed feelings, seeing him vulnerable like this. On one hand, she would be glad that he's showing this side to her, but on the other hand, she would be worried about his state of mind. Throughout, she would be gentle yet firm in handling him.
Sakura would be over the moon. She would blush deeply and look at Sasuke with so much love in her eyes. She might be at a loss for words for a moment, but then she would find her voice and tell Sasuke that she has been waiting for this moment her whole life. She would also feel a sense of pride that Sasuke has chosen her, after all they have been through. And she would immediately start thinking about how to share the good news with their friends, especially Naruto, who has been like a brother to her and has also been a part of their journey.
In some fanfictions, Sakura may be determined to find Sasuke and bring him back. She could set out on her own journey, facing various challenges along the way, and growing both as a person and as a ninja in the process of trying to reunite with him.
Sakura's reaction would depend on how the author writes her character development. If she's become more confident in herself, she might approach Sasuke with a more assertive attitude. She could tell him that she's not the same girl he left behind. However, she'd still have that underlying love for him. She might also be worried about how the village will accept Sasuke's return and how it will affect her standing in Konoha. So her reaction would be a complex blend of personal feelings and concerns for the village.
She could be heartbroken. Sakura has always loved Sasuke deeply, so his leaving for Naruto would be a huge blow to her. She might initially be in denial, not believing that Sasuke would choose Naruto over her.
Sakura might be heartbroken. She's been in love with Sasuke for so long. She could initially go into denial, thinking it's just a temporary thing. Then she might get angry and vow to prove herself to Sasuke, perhaps by becoming an even stronger ninja.
Sakura could also try to stand up for herself. If she believes that Sasuke is being unfair in his anger, she may argue back. For instance, if Sasuke is angry because of a misunderstanding, Sakura might try to clarify the situation and prove her point.
Sakura would probably be initially shocked and angry. She has always cared about Sasuke, and this betrayal would hit her hard. But she is also a strong - willed ninja. So, she would quickly gather her wits and start looking for ways to escape. She might try to use her knowledge of Sasuke's fighting style against him if she gets the chance.
In some fanfictions, Sakura's reaction could be more complex. She might be hurt not just physically but also emotionally. This could lead her to question her relationship with Sasuke and might cause her to make some big decisions, like whether to continue trying to reach out to him or to cut him off completely.
She may initially be angry. Sakura is a proud and strong character. She could confront Sasuke and Ino, demanding an explanation. After that, she might decide to become even stronger, both in her ninja skills and her emotional resilience, to show Sasuke what he's missing.
Sakura could also be more composed in her reaction. Given her growth as a character, she might try to reason with Sasuke first. She could say things like 'Sasuke, I know you must have a reason for this. Let's talk about it.' However, if Sasuke doesn't respond or seems hostile, she may start to feel betrayed. She might then use her medical ninjutsu knowledge to try to find a weakness in the snakes or in Sasuke's technique that is keeping her tied up. She could also start thinking about how she can turn the situation around and make Sasuke see reason.