Perhaps she's a sister who was thought to be dead but actually survived. She could have been corrupted by the experiences she had while being 'dead'. When she returns, she blames Percy for not saving her properly. This false blame leads her to betray Percy. She could start spreading rumors about Percy being a coward or a bad leader among the demigod community.
The sister could be under the control of a powerful god or goddess who has a grudge against Percy. She might be forced to betray him. For instance, she could lead Percy into a trap set by the god. She could lie to him about a mission, saying it's a rescue mission but in fact it's a trap where the god is waiting to take revenge on Percy for some past deeds. This would be a really heart - breaking betrayal for Percy as he trusts his sister.
Perhaps a powerful sorceress from an ancient line that has a long - standing grudge against the demigods. She sees the sister as an easy target at first, but as the story progresses, she realizes that the sister is much stronger and more determined than she thought. So she becomes more and more desperate to defeat her and stop her from fulfilling her destiny.
One possible plot could be Percy feeling a deep sense of betrayal and loneliness. He might struggle with his self - worth as he wonders why his sister left him. This could lead him on a journey to find answers about his family and his own identity, perhaps even uncovering secrets about his demigod heritage that his sister knew and he didn't.
Well, one possibility could be that the sister discovers she has some unique powers that are different from Percy's. For example, she might be able to communicate with mythical creatures in a way that no one else can. This could lead to her getting involved in a quest to save a particular part of the mythical world that is in danger.
The gods are always a possibility. Zeus, for example, has been distrustful of Percy in the past. If Zeus feels that Percy is getting too powerful or is a threat to his rule, he could engineer a situation where Percy is betrayed. He might use other demigods or even mortals to turn against Percy.
There's a chance that it could be a character from Percy's family. For example, a distant relative who has been corrupted by some dark magic. They might betray Percy for their own gain or because they are being controlled, and this betrayal could lead to Percy being killed.
It could be a vengeful god. Maybe a god who feels that the sister's existence is an insult to their power. So they set out to stop Percy from finding her. For example, Hades might be the antagonist if he believes that the sister's return could disrupt the order in the Underworld.
Well, sometimes in fanfiction, his brother might be a mortal who discovers his demigod heritage later. This could add an interesting twist to the story as he has to adapt to the world of gods and monsters. Or it could be a long - lost half - brother from a different camp, like a son of Poseidon from another part of the world who was hidden away for some reason.
Luke might be the one to betray Percy again in a fanfiction. Even if he had a change of heart before, perhaps in this fanfiction he's been influenced by some dark force once more. He could pretend to be on Percy's side and then stab him in the back when Percy least expects it.
A common theme is the discovery of the sister's powers. For example, she might find out she can control water like Percy but in a different way. This adds an interesting twist to the story as they learn to use their powers together.