It could be another monster who is jealous of Sans' new form. This monster might feel that Sans is getting special treatment or opportunities because he's now a human. So, this jealous monster tries to find a way to either turn Sans back into a skeleton against his will or make his human life miserable by causing trouble for him in the human world, like spreading false rumors about him.
Maybe the main antagonist is the force or entity that caused Sans to turn into a human in the first place. If it was a magical curse, the source of the curse might not want Sans to break it. So, it sends various obstacles in Sans' path as he tries to find a way to reverse the transformation. These obstacles could be in the form of dangerous creatures or illusions that try to deceive Sans and keep him from achieving his goal.
It could be another monster who is jealous of Sans getting all this new - found attention as he turns into a human. This monster might try to stop the transformation process or make Sans' life difficult in his new human form.
Perhaps an evil mage who actually intended for the transformation to go wrong on purpose. They might want to use Sans' new female form to cause chaos in the Underground. They could be trying to manipulate Sans into doing bad things or using her to get to other important characters.
Dr. Eggman would be an obvious choice. Since Sonic is now in a more vulnerable human form, Eggman could see this as the perfect opportunity to finally defeat Sonic and take over the world. He might come up with new devious plans, like creating robots specifically designed to target a human Sonic.
Perhaps there could be a jealous teacher in the school where he starts working as a human. This teacher is threatened by Koro Sensei's popularity among students, even though he's now human. So, this teacher starts to spread rumors or create problems for him to get him fired.
Maybe in the fanfiction, there's a scientific experiment gone wrong. A human scientist was trying to find a way to bridge the gap between humans and monsters. Sans, being a curious skeleton, volunteered to be a part of the experiment. However, instead of just creating a connection, the experiment transforms Sans into a human. As a human, he experiences new emotions more intensely, like hunger and fatigue, which he didn't really have as a skeleton. He then uses his new human form to try and convince other humans that monsters are not to be feared.
Well, one possible plot could be that Sans discovers a mysterious magic spell or artifact that gradually transforms him into a human. As he changes, he has to deal with new sensations like feeling pain and hunger in a more intense way. He also might struggle with how other characters in the Undertale world view him now that he's different.
It could be an ancient dark wizard who has been manipulating events from the shadows. This wizard might see Elsword as a powerful tool and has been slowly influencing him to turn dark. The wizard could be using dark magic to cloud Elsword's mind and make him more susceptible to negative emotions.
Bowser could be the main antagonist. He might see Luigi's transformation as an opportunity to mess with Mario and the Mushroom Kingdom. He could try to use Luigi's new form to his advantage, perhaps by trying to make Luigi a spy or by using his new identity to cause chaos among the kingdom's residents.
It could be a jealous rival. Maybe someone who has always been envious of Robin's abilities or popularity. Now that Robin is in a more vulnerable state as a girl, this rival sees an opportunity to undermine him.
It could be a witch who cast the spell that turned Dean into a girl. This witch might have some ulterior motives, like using Dean's new form to disrupt the balance in the hunting world. Maybe she wants to create chaos among hunters by making them question Dean's abilities now that he's a girl.