She could be angry at first. Tsunade has always been a strong - willed leader, and Naruto leaving without proper communication might seem like a sign of disrespect to her.
In some fanfictions, Tsunade could be understanding. She realizes that Naruto has his own journey to take, and she respects his decision to leave, although she may not fully agree with it. She hopes that Naruto will return stronger and more capable.
He could become determined to prove his innocence. Naruto is not one to give up easily. If he was wrongly banished, he would set out on a journey to find evidence or the real culprit to clear his name and return to the village he loves.
Naruto might be initially confused. He trusts Tsunade, so being kidnapped by her would be completely unexpected. He would probably start by asking her why she's doing this.
Sakura might also get angry. She could feel that Naruto is being unfair or cowardly. She might try to find Naruto and confront him about why he left her alone. In the process, she could end up growing stronger both physically and emotionally. For example, she might train harder to prove to Naruto that she doesn't need him around. And also, she could start to re - evaluate her own feelings and relationships in general.
His family could be initially shocked and heartbroken. For example, his wife might be left in a state of disbelief, wondering why he would leave without much explanation.
Naruto might initially be in denial. He's so used to having Sakura around and believing that they have a future together. So when she leaves for Sasuke, he might think it's just a temporary thing or that she's been influenced by something or someone. But as time passes and he realizes it's real, he would be deeply hurt. He might also start to question his own self - worth, thinking that he wasn't good enough for Sakura. And he might even try to win her back at first, but then slowly come to accept the situation and focus on his other responsibilities like being a ninja and protecting the village.
At first, Naruto might be extremely shocked. He has always seen Tsunade as a respected figure. So when she hurts him, he may not be able to immediately process it. He could be speechless and just stare at her in disbelief.
Well, in some fanfictions, Tsunade might be devastated. She could go into a state of deep grief and self - blame, thinking she could have done more to prevent Naruto's death. After all, she was his Hokage and had a certain level of responsibility for him.
He could feel a sense of guilt. Sasuke might think that his actions or their relationship issues pushed Naruto to leave. He may then set out to find Naruto, not only to bring him back but also to resolve their long - standing issues. For example, if there were unspoken words or unresolved fights between them, Sasuke would see this as an opportunity to set things right.
Some members of the pack might be angry at first. They could see his leaving as a betrayal, especially if they are in the middle of a difficult situation and rely on him in some way.
She might be initially shocked. Given her own past traumas and her relationship with Naruto, she could be hesitant at first. But then, considering Naruto's lonely situation, she might warm up to the idea and show a more maternal side towards him.