Well, in some fanfictions, Tsunade might be devastated. She could go into a state of deep grief and self - blame, thinking she could have done more to prevent Naruto's death. After all, she was his Hokage and had a certain level of responsibility for him.
There are also fanfictions where Tsunade's reaction is a complex mix of emotions. She could be both heartbroken and angry at the same time. Angry at the circumstances or the enemies that led to Naruto's death. She might start investigating the cause of his death with a vengeance, vowing to make those responsible pay, while also mourning the loss of one of the village's most important and beloved shinobi.
In other fanfictions, Tsunade's reaction could be more of a cold determination. She might use Naruto's death as a catalyst to bring about major changes in the Hidden Leaf. Maybe she decides to toughen up the village's defenses and training regimens so that no more young shinobi would meet such a tragic end like Naruto.
Tsunade herself would be in a state of shock and deep remorse. She might blame herself for Naruto's death, thinking that she should have been stronger and not needed saving. The villagers would also be greatly affected. The children who looked up to Naruto as a hero would be heartbroken. They would start to tell stories about his bravery, and some might even be inspired to become like him, despite his tragic end.
Naruto might be initially confused. He trusts Tsunade, so being kidnapped by her would be completely unexpected. He would probably start by asking her why she's doing this.
He would feel a deep sense of guilt, thinking that if he had been stronger or more aware, he could have saved her. Naruto might also start to cherish the memories he had with Hinata more, and this could change his personality a bit, making him more somber at times. He would probably vow to protect the things that Hinata held dear, like her family and the village.
At first, Naruto might be extremely shocked. He has always seen Tsunade as a respected figure. So when she hurts him, he may not be able to immediately process it. He could be speechless and just stare at her in disbelief.
He could become determined to prove his innocence. Naruto is not one to give up easily. If he was wrongly banished, he would set out on a journey to find evidence or the real culprit to clear his name and return to the village he loves.
She could be angry at first. Tsunade has always been a strong - willed leader, and Naruto leaving without proper communication might seem like a sign of disrespect to her.
The villagers would likely be shocked. Naruto is a hero to many in Konoha, and Tsunade is the Hokage. Their sudden departure would cause a great deal of confusion and concern. Some might think that Konoha is in danger if two such important figures have left.
He would be filled with a deep sense of grief. Naruto has always cared about Hinata, and her death would be like a part of him has been ripped away. He might isolate himself for a while, blaming himself for not being able to protect her. But eventually, he would use his pain as motivation to get stronger and fight against whatever caused her death.
She might be initially shocked. Given her own past traumas and her relationship with Naruto, she could be hesitant at first. But then, considering Naruto's lonely situation, she might warm up to the idea and show a more maternal side towards him.
Naruto might also try to remember Sakura in a positive way. He would cherish the memories they had together. He could start initiatives in the village in her name, like promoting medical ninja training more, since Sakura was a great medical ninja. He would slowly turn his grief into a force for good in the village.