A plot could involve a school competition where both Flash and Peter are competing. Flash is overconfident, while Peter is underestimated. However, Peter uses his smarts and Spider - Man - like agility (in a non - obvious way) to start winning. Flash gets jealous at first but then realizes that he can learn from Peter. This leads to a series of interactions where they learn to respect and support each other, and their relationship evolves from antagonistic to friendly.
One idea could be Ava and Peter teaming up to face a new super - villain in the city. Maybe this villain has the ability to manipulate time, and Ava's powers along with Peter's Spider - Man skills are needed to stop the chaos. Another plot could be a story where Ava and Peter get transported to an alternate dimension and have to find their way back while dealing with the different versions of their friends and foes there.
Perhaps there's a plot where an alien symbiote attaches itself to Mary Jane instead of Peter. She starts to develop strange powers and a more aggressive personality. Peter has to figure out how to save her from the symbiote's control. This would put a strain on their relationship as Mary Jane struggles with the new - found power and Peter tries to be the hero she needs.
One interesting plot idea could be Spider - Man teaming up with unexpected heroes from other universes. For example, he might work with a magical hero to fight a villain who has the ability to manipulate time. This would create a really cool dynamic as they combine their different skills and powers.
A plot could involve Harry getting powers as well, not just from the Goblin formula but in a different way related to some Oscorp experiment. He and Peter then have to figure out how to control their powers together and face a new supervillain created by Oscorp's misdeeds. It would add a new dynamic to their relationship as they both struggle with their newfound abilities.
One idea could be a gender - bended Spider - Man facing different social expectations. For example, in the regular story, Peter Parker has his own set of challenges as a male superhero, but a female version might have to deal with things like being underestimated in a male - dominated superhero world. She could also have different relationships with the other characters. Maybe her friendship with Harry Osborn or her interactions with Aunt May would be more nuanced due to her being female.
One idea could be a crossover with the X - Men. Spider - Man could find himself in the middle of a conflict between mutants and anti - mutant forces. He'd have to use his quick thinking and agility to help the X - Men protect the young mutants. Another could be a crossover with the Fantastic Four. Maybe Spider - Man gets caught in one of Reed Richards' experiments gone wrong and they all have to work together to fix it while also dealing with a new super - villain that emerges from the chaos.
A plot could involve the Spider - Man team getting stranded in an alternate dimension. They would have to find a way to get back home while also dealing with the unique challenges and threats of that dimension. This could include new villains, different versions of themselves, and strange new powers.
One idea could be a team - up where Spider - Man and Thor have to face a common enemy that can manipulate time. Spider - Man uses his agility and quick thinking, while Thor wields his hammer and godly powers. Another could be a story where Spider - Man accidentally gets sent to Asgard and Thor has to help him get back home while also dealing with the chaos Spider - Man causes in Asgard.
Another plot idea is a time - travel story. Spider - Man gets sent back in time to when his uncle was still alive. He has to make sure that his actions in the past don't accidentally change the future too much while also trying to learn some valuable lessons from his younger self and his uncle. This could lead to some really emotional moments and also some interesting battles as he might face off against villains that were active during that time in a different way than he did in his own time.
One unique way is if Flash has a family problem, like his parents are getting divorced. Peter, being the empathetic person he is, tries to help Flash through it. Flash is initially resistant but then realizes Peter's genuine kindness. This experience changes their dynamic as Flash becomes more vulnerable around Peter, and Peter becomes someone Flash can trust. They then form a deeper connection that goes beyond their typical school - based interactions.