Perhaps Kakashi feels that Naruto is becoming too reliant on him and not developing his own skills independently. So, in order to force Naruto to become stronger on his own, he decides to abandon him. This is a tough - love approach. Naruto has great potential, but he needs to learn to stand on his own two feet, and Kakashi may think this is the best way to make that happen.
One possible reason could be that Sakura realizes she has different goals or values that are not compatible with being around Naruto. Maybe she discovers a new path in life that doesn't involve him, such as focusing on her own medical ninja career without Naruto's chaotic lifestyle interfering.
In some fanfictions, Naruto might abandon his family due to a false prophecy that convinces him he's a danger to them. He may think that by leaving, he can protect them from harm that might come his way because of his past or enemies.
One possible reason could be that Kakashi is preoccupied with other important matters in the village. Maybe he has some top - secret missions or tasks assigned by the Hokage that demand his full attention, leaving him with little time to focus on Naruto.
One possible reason could be that Naruto might feel Kakashi is too strict with his training. Maybe Kakashi's methods are too harsh for Naruto, making him frustrated and gradually developing dislike.
One possible reason could be Kakashi's reputation as a strict and powerful teacher. Naruto might be in awe of his skills and fear making mistakes in front of him.
One possible reason could be that Naruto might be trying to prove his independence. He has grown and wants to show that he can handle things on his own without always relying on Kakashi's guidance.
One possible reason could be some sort of dark influence or curse that makes her lose her maternal instincts. Maybe a powerful enemy targets her and in order to protect Naruto from further danger related to her, she feels forced to abandon him. Another reason might be that she is made to believe false information about Naruto, such as that he will bring great disaster to the village in the future.
One possible reason could be that Naruto discovers some dark secrets about the village leadership that go against his values. For example, if he finds out that they have been using underhanded means to maintain power.
Perhaps the fanfiction alters the relationship between Kakashi and Naruto in a way that Kakashi doesn't like. Maybe it shows Kakashi as being overly harsh or unfair to Naruto in a situation where in the original series he wouldn't be. It could also be that the fanfiction contains plot elements that Kakashi, as a character, would find illogical or against the spirit of the Naruto world.
One reason might be that he doesn't like how fanfiction can change the relationships between characters. For example, in the original, his relationship with Naruto is based on training and mentorship, but fanfiction could make it something completely different.