A powerful and ancient Kryptonian entity that was sealed away long ago could be the main antagonist. It breaks free due to some events and wants to reshape Krypton according to its own dark desires. The reborn character, with their new - found powers and different perspective, stands in its way. Also, there could be a group of Kryptonian zealots who oppose any change in the traditional Kryptonian ways. They see the reborn character as a threat to their way of life and try to get rid of them.
It could be a powerful ninja who has made a deal with an otherworldly force to gain powers to match Naruto's. This antagonist might be jealous of Naruto's unique heritage and wants to prove that pure ninja power is superior. So, he uses dark magic or forbidden jutsu to become a formidable foe.
Lex Luthor would be a classic choice. He could be jealous of the protagonist who is reborn as Superman and see him as a threat to his own power and influence. Luthor might try to use his intellect to create new weapons or strategies to defeat Superman.
It could be a new character created specifically for the fanfiction. Maybe a powerful pirate who has a vendetta against the Straw Hat crew because of the oc's presence. Since the oc is reborn into this world, they might bring some sort of change that angers this new antagonist.
It could be a new character who has the ability to disrupt both Lambo's time - traveling powers and the Reborn characters' mafia - based powers. This antagonist might be after a powerful artifact that Lambo and the Reborn crew are protecting.
The goddess Hera might also be a great antagonist. Since she has a history of interfering in the lives of demigods, she could be jealous or threatened by Percy's rebirth. She might try to stop him from reaching his full potential in his new life or cause trouble between him and his new allies.
The Green Goblin could be a great main antagonist even in a Spider Man reborn story. Maybe in this version, he has developed a new form of insanity - inducing gas that affects Spider Man's new powers. Another possibility is Doctor Octopus. He could have found a way to merge his mechanical arms with some sort of alien technology, making him far more powerful and a real threat to Spider Man reborn.
It could be a rogue ninja who has discovered some ancient and dangerous jutsu that Tobirama once sealed away. This antagonist would be seeking to use the jutsu for their own evil purposes and Tobirama, in his reborn state, has to stop them.
Maybe there is a new character created specifically for this fanfiction as the main antagonist. This new character could have a connection to the oc's past life or the reason for their rebirth. They might be trying to prevent the oc from fulfilling a certain destiny or unlocking their full potential.
It could be an ancient evil that was sealed away long ago but has been released due to Naruto's death. Maybe Naruto's sacrifice in his previous life weakened the seal, and now this evil has emerged. It could be a powerful demon or a dark ninja with extremely strong and malevolent jutsu.
It could be a group of Team Rocket - like villains. They are after the unique powers that the reborn pokemon might possess. Since the reborn pokemon has a human - like intelligence, they see it as a valuable asset to use for their evil plans, like stealing all the precious pokemon resources or taking over a certain region.