Well, it might make her relationships more challenging. For example, with Harry and Ron, if Hermione is a loner, she might be more distant at first. She could be hesitant to trust them fully or share her thoughts. Like, she might keep her brilliant plans to herself more often, instead of collaborating as she does in the original stories.
It can lead to more complex dynamics. Other characters might misunderstand her. They could think she's snobbish or just doesn't like them because she keeps to herself. So, it takes longer for real friendships to develop. For instance, Neville might be too intimidated to approach her if she gives off this loner vibe.
With Harry and Ron, they would become more protective of her. They'd have to learn to read her body language more carefully. For example, when she used to shout out answers in class, now she'd have to communicate her thoughts through gestures, and they'd have to be more attentive. And with Snape, he might initially think she was being disrespectful by not answering verbally, but then come to understand her situation and respect her even more for her determination to continue learning despite her handicap.
Her relationship with Harry and Ron would be strained at first. They might feel betrayed or confused. But over time, if Hermione can show them that she's still the same person, they could reconcile. With the Slytherins, she might start off as an outcast but gradually earn their respect through her intelligence and determination.
Her relationship with Harry and Ron would be very different. They might be initially scared or at least very cautious around her. But their friendship could also be strengthened as they try to understand and support her through her new situation. With teachers like Dumbledore, he might be more watchful over her, seeing her as both a potential danger and an interesting case. Hermione herself would probably feel isolated from her peers at first.
It often weakens his relationships with Ron and Hermione. Instead of relying on them, he may distance himself. For example, he might not share his problems with them as he used to.
Her relationship with Ron would be severely tested. Ron, who has some prejudices in the original story, might initially be scared or repulsed by Hermione's werewolf side. But over time, he could come to accept her and see that she's still the same Hermione he knew.
Her relationship with Harry might become more of a protector - protected dynamic. Harry would be in awe of her new powers and might rely on her more in dangerous situations. With Ron, there could be some jealousy at first as he might feel left out. But eventually, he'd see the value of her powers and they'd become closer in a different way. And with the professors, they would either be intrigued and want to study her powers or be a bit cautious in case the powers got out of control.
With Harry and Ron, their initial reaction would probably be shock. They might have a hard time trusting her at first, but as they realize it's still Hermione inside, they would come around. However, they would also be worried about how others would perceive her. As for Draco, he might be more afraid of her initially, given Bellatrix's reputation. But if Hermione showed her true self through her actions, he could start to see her in a different light.
It could really strain her relationship with Ron especially. He has a bit of a prejudice against Slytherin - related things, and this snake - speaking ability is something that he might find hard to accept. However, Hermione could use this as an opportunity to educate him and others about not judging things based on old biases. She might start to have a new connection with Neville, who is also often underestimated, as they both have unique abilities that others might not fully understand at first.
Her relationship with the teachers would also shift. Professors like Flitwick might take a special interest in her as a Ravenclaw. He could give her extra - curricular projects related to advanced charms. And Snape might be a bit more begrudgingly respectful of her Ravenclaw intelligence, seeing her as a true academic rival in the making.
If Tsuna were a girl, her relationship with her male friends might become more complex. For example, some of them might develop romantic feelings for her. Her friendships with female characters could also change. They might become more competitive or more sisterly depending on the nature of the story.