Finding food and shelter could be a challenge. Without the support of Konoha, they have to fend for themselves. They may need to hunt for food and find safe places to sleep, which could be difficult in unfamiliar territory.
They might face discrimination from other villages. Since they are from Konoha, other villages may be suspicious of them and not trust them easily.
One challenge could be the opinions of their friends. Sasuke might not understand Naruto's new interest in Ino, and Sakura could be jealous of Ino. Also, their different ninja specialties could cause some friction. Naruto is more focused on combat and large - scale ninja skills, while Ino is into mind - related jutsu and medical ninjutsu.
One challenge could be loneliness. Without other males around, he might struggle to find that sense of brotherhood or male camaraderie. He may feel isolated in some ways.
One possible reason could be to seek new powers. Maybe they feel that Konoha no longer offers the kind of training or opportunities they need to grow stronger. Another reason might be to escape from certain politics or social pressures within the village. For example, Naruto has always been an outcast in some ways, and Ino might be tired of the family business or the way things are done in Konoha.
The journey itself could be full of danger. There could be bandits or rogue ninja along the way who target Naruto because of his fame. Also, the terrain between Konoha and Kumo might be difficult to traverse, with mountains, rivers, and forests full of wild animals.
Well, it would be a big loss for Konoha. Naruto is a powerful ninja, and his absence would mean one less strong fighter to defend the village. Ino, too, has her unique skills in mind - related jutsu and communication. Their departure might also lower the morale of other ninja, especially those who were friends with them or looked up to them.
One of the main challenges Naruto might face is dealing with political intrigue within the village. There could be clans vying for more power and influence, and Naruto would have to balance their demands while keeping the overall peace. Another challenge could be external threats, like neighboring villages that might see Naruto's leadership as a chance to attack. Also, he would need to ensure the economic stability of the village, which includes things like proper resource management and trade relations.
He might face internal conflict. Naruto has always been an open and honest person, so keeping such a big secret could go against his nature. This could lead to him struggling with his conscience. Also, he would need to balance his normal life with his secret Hokage duties without raising suspicion. For instance, he can't always disappear suddenly to attend to Hokage business without people getting curious.
Naruto would face quite a few challenges. For one, his growth might be stunted as the team overprotects him. He could also face ridicule from outside the team who might see him as a weakling now. Moreover, he has to deal with the internal team dynamics where Sasuke may not be fully accepting of his new role and Naruto would have to prove himself constantly.
One major challenge could be dealing with new enemies. Outside of Konoha, there are different ninja clans and organizations that may not be friendly. They have to adapt to new fighting styles and strategies of these opponents. For instance, they might encounter powerful rogue ninjas who are more ruthless than the ones they faced in Konoha. Another challenge is that they may have to deal with their own internal conflicts while on the road. Naruto might struggle with feelings of homesickness and Sasuke with his inner demons related to his past and his thirst for revenge.
Socially, it would create a void. Ino is quite popular and has a lot of friends. Her leaving, along with Sakura's, would leave many people in the village feeling sad and missing them. It could also disrupt some of the social dynamics among the younger generation of ninjas.