One possibility is that they leave due to some sort of threat to Naruto that Konoha can't or won't protect him from. Anko, being loyal to Naruto in this fanfiction, decides to accompany him. They could start their own small ninja group, recruiting other outcasts or those who have a grudge against the major shinobi villages. They might train together, with Naruto teaching Anko some of his unique skills and Anko teaching Naruto more about the darker aspects of the ninja world that she has experienced.
They might go on a journey to discover new jutsu. Naruto's determination and Anko's experience could lead them to some secret ninja techniques hidden in far - off lands.
Well, perhaps they leave Konoha to seek answers about Naruto's parents. Anko, with her knowledge of the village's past, could help Naruto uncover secrets that Konoha has been hiding. They could end up in places like the Land of Waves or the Hidden Cloud Village in their search.
They may leave to investigate a mystery that has long been ignored or covered up by Konoha. This could be related to the origin of certain powerful jutsu or the real history of some important clans. Their departure from Konoha is a way to break free from the village - imposed limitations on knowledge and seek the truth on their own.
They could go to the Land of Fire's outskirts, where there are less - known ninja clans. Naruto might hope to learn from them and Anko could be interested in the unique fighting styles these clans possess.
One possibility is that Naruto is being captured for a misunderstanding. Maybe Konoha has received false information about Naruto being a threat. In the fanfiction, this could lead to his friends having to prove his innocence.
One possible scenario is that Naruto starts to learn new and unique jutsus from Itachi. Itachi is highly skilled, and he could pass on some of his knowledge about the Sharingan and powerful genjutsu. Naruto, with his determination and Itachi's guidance, might become even stronger, and they could form a plan to deal with the threats to Konoha that they both know exist.
Another scenario is that Naruto leaves because he feels like an outcast with the Rinnegan. The villagers might fear his new power, and he decides to leave to find a place where he can fully understand and control the Rinnegan without causing panic. He could then encounter other powerful ninjas or groups who either want to use him for his power or help him master it.
Well, one possibility is that Hinata decides to go after Naruto. She's in love with him, after all. She might leave Konoha too, in search of him. This could lead to a whole adventure where they meet new characters and face new challenges together. It would also be a chance for their relationship to develop further outside the constraints of the village.
One possibility is that Naruto would return with newfound strength and wisdom. He might have learned unique techniques during his time away. Konoha could welcome him with open arms and immediately put his skills to use in protecting the village. For example, he could train the new generation of ninja, sharing his experiences from his travels.
One possibility is that the villagers' perception of Naruto changes. They might start to see him in a new light, perhaps with more respect as they realize his connection to the Namikaze clan. It could also lead to some of the older villagers reflecting on Minato Namikaze and how Naruto might carry on his legacy in ways they hadn't considered before.
Well, they could go on a journey to explore new lands. Maybe they'll discover a hidden village with unique ninja techniques. They might meet new friends or face new enemies along the way.
Well, one possibility is that Anko would feel a great sense of relief. Naruto might discover some hidden power or ability that was being suppressed by the seal. Maybe it could lead to Anko being able to use new jutsus or have enhanced physical capabilities. It could also change her relationship with Naruto, as she might be very grateful to him for removing the seal.