The plot might involve Nurse Redheart getting overwhelmed with patients during a big event like the Grand Galloping Gala. She has to manage all the minor injuries and ailments that the ponies get while trying to keep her cool. And along the way, she could learn some valuable lessons about asking for help when she needs it.
She is usually shown as being highly intelligent when it comes to medical knowledge. She can quickly diagnose an illness or injury just by looking at the symptoms. And she's always up - to - date with the latest medical research in the pony world. In some fanfics, she's also a bit of a perfectionist, wanting to make sure every patient gets the best possible care.
One possibility could be a story where Spike sacrifices himself to save his friends. Maybe there's a great danger in Equestria, like a powerful dark magic that only Spike can stop because of his unique dragon abilities. He might use his fire to counter the dark magic but in the process, exhausts all his energy and dies. His friends are left to mourn his loss but also remember him as a hero.
One possible plot could be that Naruto gets seriously injured during a mission. Tsunade, as the best medical ninja, takes on the role of his nurse. She not only heals his physical wounds but also helps him deal with the emotional trauma of the battle. Through this process, Naruto gains a new level of respect for Tsunade's skills and they develop a deeper bond as comrades.
Perhaps the story in the 'drunk mlp fanfic' is centered around a group of ponies who accidentally consume some enchanted cider that makes them drunk. They then start seeing strange visions and go on a wacky journey to find a cure, all while their normal pony friends are trying to figure out what's wrong with them.
Maybe the nurse reader could be a witness in one of Olivia's cases. They start to interact more as the case progresses, and a friendship or something more could develop. For example, the nurse might have some crucial information that helps Olivia solve the case, and in the process, they find they have a lot in common.
Well, it could be about Starlight feeling wronged by the ponies in Ponyville. Maybe she decides to take revenge because she was excluded from some important events. So she starts using her magic to create small troubles for the ponies, like making their crops grow slowly or causing minor chaos during their festivals.
The plot might center around a portal that opens between the two worlds. The Hyrule Warriors characters, such as Link or Zelda, are transported to Equestria. There, they discover that the chaos in their own world is somehow related to a disturbance in the harmony of Equestria. So, they join forces with the ponies, like Twilight Sparkle and her friends. Along the way, they face challenges that require both the brute strength and combat expertise of the Hyrule Warriors and the magical abilities and friendship power of the ponies.
Perhaps in the fanfic, Luna has a nightmare about her past as Nightmare Moon. She wakes up crying because she fears that she could lose control again and turn back into that evil form. This would show her internal struggle with her own identity and the fear of repeating her past mistakes.
One possible plot could be that a pony has a really bad toothache and has to visit the dentist pony in Ponyville. The dentist pony discovers that there's a magical element causing the toothache and has to find a way to fix it without harming the patient. It could involve a journey to find a special herb or spell.
One possible plot could be that the ponies accidentally end up in the Attack on Titan world through some sort of magical portal. They then have to figure out how to survive in this harsh environment. They could use their unique pony abilities, like Fluttershy's connection with animals, to try and understand the Titans better. Maybe they could even find a way to communicate with the Titans and find out if there's a way to stop the attacks without all the bloodshed.