A plotline could also be that Naruto is lost in space and finds himself on a planet that is in the middle of a magical crisis. Despite not being familiar with the magic there, he uses his ninja spirit and willpower to help. He might team up with a local wizard or sorceress who is impressed by his determination. They would then work together to defeat an evil force that is draining the planet's life force. Naruto's ability to never give up would be a key factor in this adventure.
Another plot could be that she was raised in a different village under false pretenses, believing she was an orphan. When she discovers she is Naruto's sister, she has to decide whether to stay in the village she grew up in or return to Konoha. Along the way, she has to face her own identity crisis and deal with the political implications of her new - found family relation.
It could involve space exploration, discovering new planets, or encountering alien civilizations.
The plot could also involve a time - related crisis. Maybe something is threatening the timeline, and the only way to fix it is for future Naruto to raise his younger self in a certain way. So, future Naruto has to make sure that the younger Naruto grows up to be strong enough to face this threat while also maintaining the integrity of the timeline.
Perhaps the Human Tenno is seen as a threat by Cerberus. They start hunting the Tenno down. The Tenno has to constantly be on the run, hiding on different planets. They might meet some friendly Mass Effect characters who help them, like Liara T'Soni. The Tenno could then use their unique abilities, like their Warframe powers, to fight off Cerberus attacks and in the process, learn more about the secrets of the Mass Effect universe and how it might be related to their own world.
One possible plotline could be that Sakura realizes she has lost her chance with Naruto after he has found love with someone else. She then has to deal with her unrequited love and find a way to move on. Maybe she focuses more on her medical ninja skills and becomes a renowned healer in the village.
One possible plotline could be that Naruto somehow ends up in Akeno's world. They meet and at first Akeno is a bit shy around Naruto. Naruto, with his positive attitude, gradually befriends her. They could go on adventures together, like facing some common enemies in Akeno's realm. Naruto's ninja skills would be very useful in such situations.
One possible plotline could be that Naruto is in a life - threatening battle against a powerful enemy. Gaara arrives just in time, using his sand powers to shield Naruto from a fatal attack. Then they team up, with Gaara's strategic thinking and Naruto's unwavering determination, they gradually turn the tide of the battle.
One possible plotline could be that Naruto is somehow mind - controlled. Maybe an enemy uses a powerful genjutsu on him, making him see the Konoha 12 as threats to the village instead of comrades. This would lead to a tragic situation where Naruto, in his altered state of mind, attacks them.
Perhaps the plot could start with Yugito initially being a normal acquaintance of Naruto. But after some incident, like Naruto saving her life, her feelings turn into a yandere - like obsession. She then starts following Naruto everywhere, much to his confusion at first. As the story progresses, Naruto has to figure out how to deal with her obsessive behavior without hurting her feelings too much, while also maintaining his own goals and relationships.
One possible plotline could be that Kumo is under attack by a powerful and mysterious enemy. Naruto, being the hero he is, hears about it and rushes to save the day. He might use his newfound Sage Mode powers or his ability to connect with the Nine - Tails to fend off the attackers.