It could be another basketball team. They might be jealous of the Generation of Miracles' talent and see Alex as a threat when he teams up with them. So they try to undermine their performance during important games.
Perhaps a coach from a rival school. This coach is known for his cut - throat tactics and wants to break the bond between Alex and the Generation of Miracles. He might spread false rumors about Alex to create distrust within the group. He would be constantly devising plans to make them lose their focus on the game and their unity.
One idea could be that Alex has a unique basketball skill that catches the attention of the Generation of Miracles. They initially challenge him but then realize they can learn from each other.
It could be an ex - partner of either Alex or Mandy. For example, if Alex has an ex - girlfriend who still has feelings for him and doesn't want to see him with Mandy. She might try to sabotage their relationship by spreading false rumors or causing misunderstandings between them.
A good antagonist could be a character from the 'Resident Evil' universe, like Albert Wesker. His superhuman abilities and evil plans for global domination would pose a huge threat to Alex Rider. Alex would have to use his wits and skills to stop Wesker's bio - terrorist plans.
It could be a powerful and shadowy figure from Wolf's past, like an old military commander who has gone rogue. This person might have a vendetta against Wolf for some past betrayal and sees Alex as a way to get to Wolf, using Alex's importance in the spy world as leverage.
It could be a powerful warlock who has found a way to manipulate time and space. He wants to stop Paige and Prue from joining forces because he fears their combined power. So he creates various obstacles and illusions to keep them apart.
Maybe a powerful rogue ninja who has discovered a way to steal the powers of divine entities. He sets his sights on Amaterasu and Naruto because he knows that if he can combine their powers, he will be unstoppable. He creates various traps and illusions to separate them and weaken them so that he can carry out his evil plan.
A powerful new pirate group could be the main antagonist. They might be after the same treasure or territory as Luffy and Shanks. They could have some unique and dangerous abilities, like the ability to control sea monsters. Their leader could be a former crewmate of a well - known and feared pirate, who has his own vendetta against both Luffy and Shanks for some past reasons.
There could be an ancient force that is awakened by the meeting of Harry and Hela. This force wants to destroy both of them because their combined powers could potentially stop it from achieving its goal of spreading chaos and destruction throughout all the realms. It would use all kinds of devious means to try and separate them and defeat them one by one.
Maybe a powerful warlord from Negan's world who somehow follows him into Artemis' realm. This warlord, with his own thirst for power and destruction, would oppose both Negan (if he starts to side with Artemis) and Artemis herself, wanting to take over the new world he has found.
It could be another god who is jealous of Zeus' interest in Atreus. Maybe a god who feels that Atreus is an outsider and doesn't belong in their divine affairs.