Another plot twist could be that Orochimaru has made a pact with some unknown and powerful entity from another dimension. This entity gives him powers that are beyond comprehension. As a result, Naruto has to not only face Orochimaru but also figure out how to deal with this new and mysterious power source that Orochimaru has acquired.
Perhaps Orochimaru comes back with an army of clones that are not like the normal clones. These clones could have the ability to absorb the chakra of the opponents they fight, making them stronger with each battle. And Naruto would have to find a way to counter this strange new threat.
Well, one possible plot twist could be that Orochimaru returns with a new and more powerful form of his jutsu. Maybe he has found a way to combine different elemental jutsus in a way that no one has ever seen before. This would pose a huge threat to Naruto and his friends.
One possible plot twist could be that Naruto's 'godlike' powers are not his own but are the result of some ancient curse placed on Orochimaru that backfires. For example, Orochimaru was trying to gain ultimate power and in the process, he unknowingly transferred a powerful and uncontrollable energy to Naruto. So when Naruto kills Orochimaru, it's like the curse has completed its cycle. Another aspect could be the emotional turmoil Naruto goes through. Even though he has to kill Orochimaru for the greater good, it still weighs on his conscience because Naruto is a character who values all life. He might struggle with the idea that he had to take a life, even if it was someone as evil as Orochimaru.
Well, perhaps in the fanfiction, Naruto kills Orochimaru and the Akatsuki, but it turns out that Orochimaru had a failsafe. His death triggers a powerful curse that starts to affect Naruto and the Hidden Leaf Village. Naruto then has to find a way to break this curse while also dealing with the remaining threats that were associated with the Akatsuki. It could be a race against time to save the village and himself.
Well, in a Good Orochimaru Adopts Naruto fanfiction, the plot could take an interesting turn when Orochimaru tries to train Naruto. Since Orochimaru has such different and often dark jutsu, Naruto might struggle to adapt. But this could lead to Naruto creating his own unique style of combat that combines his Uzumaki resilience with some of Orochimaru's knowledge. And then there's the matter of how the rest of the village reacts. They might be very suspicious of Orochimaru's intentions and try to take Naruto away, which would create a whole new set of conflicts.
A plot twist might be that Naruto and Sasuke discover a hidden agenda Orochimaru has that involves someone they care about deeply. For example, they find out he's planning to use Sakura as a sacrifice for some dark ritual. This would force them to quickly come up with a plan to rescue her and stop Orochimaru once and for all.
It could be that the bite was part of a larger plan by Orochimaru to create a new body for himself. Orochimaru is always seeking new vessels. He might think that Naruto, with his strong chakra and willpower, would be the perfect host. So, Naruto has to fight against Orochimaru's influence from within his own body, while also trying to figure out how to stop Orochimaru's overall plan.
One possible plot twist could be that Orochimaru turns Naruto into a girl as part of a grand experiment. But Naruto, now a girl, still has his (or rather her) strong will and uses this new form to infiltrate an all - female group that Orochimaru wants to target. This way, Naruto can gather intelligence and thwart Orochimaru's plans from the inside.
One possible plot twist could be that Sakura initially joins Orochimaru to gain more power to protect her friends, but she soon discovers that Orochimaru has ulterior motives regarding her unique chakra abilities. For example, he might want to use her as a vessel for some dark jutsu. Another twist could be that Orochimaru's henchmen start to develop loyalty towards Sakura instead of him because of her strong will and medical skills. This could lead to a split within Orochimaru's group, with some siding with Sakura and others remaining with Orochimaru.
One possible plot twist could be that Orochimaru was actually being controlled by a greater evil, and Naruto has to not only save Hinata but also deal with this hidden threat. Maybe Orochimaru was forced to target Hinata to draw Naruto out for this other entity's purposes.
One possible plot twist could be that Naruto is captured but instead of Orochimaru using him for his own power gain immediately, he tries to turn Naruto against Konoha. He might show Naruto some 'hidden truths' about the village that are actually lies or half - truths, creating internal conflict within Naruto. Another twist could be that Orochimaru's experiment on Naruto goes wrong in an unexpected way. Maybe Naruto's chakra reacts with Orochimaru's jutsu and creates a new form of power that neither of them can control at first.
One possible plot twist could be that Orochimaru has a new jutsu that Naruto has to figure out quickly to save Sakura. Maybe it's a jutsu that messes with time, so Naruto has to break through different time loops to reach Sakura. Another could be that Orochimaru has an unexpected ally who tries to stop Naruto from rescuing Sakura. This ally could be someone from Naruto's past who has a grudge against him.