In some cases, Sakura may focus more on her own self - improvement. Realizing that Sasuke's neglect is not going to stop easily, she could decide to invest her time in becoming a stronger kunoichi, both in terms of her medical skills and combat abilities, so that she can gain Sasuke's respect, or at least be more independent.
She might be initially heartbroken. Sakura, being in love with Sasuke, would surely be deeply affected when he neglects her. She could become withdrawn herself, losing some of her usual cheerfulness.
One possible reason could be Sasuke's focus on his revenge. His thirst for vengeance against Itachi might make him blind to Sakura's feelings and neglect her as he is constantly preoccupied with getting stronger to achieve his goal of revenge.
In some fanfictions, Sakura may be determined to find Sasuke and bring him back. She could set out on her own journey, facing various challenges along the way, and growing both as a person and as a ninja in the process of trying to reunite with him.
He might be initially confused. Sasuke is not used to Sakura ignoring him as she has always been somewhat persistent in her attention towards him. So, he may be at a loss as to why she is suddenly acting this way.
Another reaction could be that Sakura tries to follow Sasuke. She believes that she can change his mind or that she can be of help to him. She might leave her own responsibilities behind for a while to chase after him, thinking that their bond is strong enough to overcome whatever is making Sasuke leave.
Sakura would probably be initially very angry. She has strong feelings for Sasuke, but kidnapping is a very extreme act. So she would likely fight back, using her medical ninjutsu skills and combat abilities to try and escape.
Sakura might be very determined to help Sasuke. She would likely use all her knowledge and resources to try and bring his memories back.
Sakura might be in shock. She probably couldn't believe that Sasuke, someone she cares about deeply, would try to kill her. So she could be frozen in place for a moment, unable to react immediately.
Sakura may initially be paralyzed by fear, but then her love for Sasuke and her own determination to survive could kick in. She might try to counter - attack in a non - lethal way, hoping to subdue Sasuke rather than harm him. She could also call out to their shared memories in an attempt to stop him from actually killing her.
Sakura could be a bit angry at first. She has grown and become more independent during his absence. When Sasuke shows regret, she may lash out, expressing all the pain and frustration she felt during his long absence, but deep down she still has feelings for him.
On the other hand, Sasuke could be very stoic about it on the surface but internally be in turmoil. He might start to analyze his own actions and whether he had missed any signs from Sakura. He could also be the type to immediately start thinking of ways to win Sakura back if he realizes he can't stand the thought of her with someone else.