The main toxic effects of isoniazid include liver damage and neurotoxicity. Isoniazid can damage liver cells, leading to elevation of transfusions, icterus, and liver cell death. When combined with rifampicin, the toxicity of the liver was significantly increased. In addition, isoniazid can also cause nervous system toxicity, manifested as peripheral neuroinflammation, abnormal sensation of limbs, loss of reflexes, muscle paralysis, and mental disorder. These adverse reactions may be related to a lack of B6.

The side effects of gardenia were as follows: - Overconsumption would cause the cold to hurt the stomach. - It is not suitable for people with loose stools due to spleen deficiency. It may cause diarrhea after taking the medicine. - Long-term use of large amounts of it would cause liver damage. - Long-term use would aggravate the symptoms of people with spleen and stomach deficiency, such as loss of appetite, loose stool, etc. In addition, gardenia tea caused many patients to develop symptoms of intestinal necrosis (intestinal mucus hemorrhage, erosion, necrosis, etc., which could lead to hematemia, chemotherapy, and even death). The novel "Smelling the Jasmine Fragrance Again" is equally exciting. Everyone is welcome to click and read it!
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Isoniazid's main function was to treat malaria. It has an antiseptic effect, mainly targeting the growth and reproduction of the MTB, and can kill or suppress the growth of MTB. In addition, isoniazid also has a certain suppressive effect on some other bacteria, such as candida candida, staph, and so on. It can also be used to treat diseases such as whooping cough and sty. Isoniazid was a widely used first-line anti-inflammatory drug. It had a good sterilization effect and few adverse reactions, and patients were usually easy to tolerate. In clinical treatment, isoniazid is often used in combination with other anti-inflammatory drugs to improve the treatment effect and prolong the time of drug resistance.
The mechanism of action of isoniazid was not completely clear, but the following conclusions were made: isoniazid was a synthetic antiseptic that had a specific effect on the bacteria. Its effect may be carried out in a variety of ways, including hindering the synthesis of Phospholiptides and mycolic acid in the cell wall of the M. tubers, causing the bacteria to lose acid resistance and proliferate and die. In addition, isoniazid can also be oxided into isonicotinic acid in the bacteria, interfering with the growth of the bacteria. It could also combine with the NAD glucose protector to affect the synthesis of DNA, and combine with the copper ions required by the fungus to make the bacteria lose its activity and play an antiseptic role. In short, isoniazid has a disinfecting effect on M. tube-like bacteria through a variety of pathways.
Isoniazid was highly selective and had a strong antiseptic effect on the bacteria. It could suppress the synthesis of mycolic acid in the wall of the fungus, causing the bacteria to lose its acid resistance, its water affinity, and its ability to proliferate. Isoniazid had a disinfecting effect on active phase of the growth of active phase of the bacili, and only had an suppressive effect on the stationary phase of the bacili. In addition, isoniazid could permeate into the cells and also had a disinfecting effect on bacteria inside and outside the cells. It was an all-purpose disinfectant and had little effect on other bacteria. However, when isoniazid was used alone, the bacteria were prone to resistance.
Isoniazid injection was mainly used to treat various types of malaria. It had a strong antiseptic effect on the bacteria, and was one of the most powerful synthetic anti-malaria drugs. It could suppress the synthesis of the cell wall of M. tubers, thereby exerting an anti-tumor effect. Isoniazid injections were usually used in combination with other anti-inflammatory drugs for the treatment of all types of malaria, including malaria and other infectious diseases. However, when using isoniazid injections, attention should be paid to the side effects that may cause liver function and nervous system. The doctor should follow the doctor's advice, monitor liver function regularly, and pay attention to clinical manifestations. In addition, isoniazid drugs are prone to drug interactions with other drugs.
Isoniazid's mechanism of action may be carried out in a variety of ways. First of all, it might cause the bacteria to lose its acid resistance and die by hindering the synthesis of phosphorus ester and mycolic acid in the cell wall of the M. tubers. Secondly, isoniazid was oxided into isonicotinic acid in the bacteria, which interfered with the metabolism process in the bacteria cells and inhibited the growth of the bacteria. In addition, isoniazid can also be combined with some of the bacteria required by the bacteria, so that the bacteria lose their activity, thereby playing an antiseptic role. Isoniazid was a synthetic antiseptic that was mainly effective against bacteria during the growth and reproduction period. It was active against both the cells and the cells. It was strong against the bacteria in the reproductive phase, but weak and slow against the bacteria in the stationary phase. Isoniazid's antiseptic effect had a high degree of selectively and specifically. It mainly had an antiseptic effect on the bacteria, but it had little effect on other bacteria.