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Does the immune preparation medicine have an effect on defecation?

2026-09-25 22:40
2026-09-25 23:59

The immune medicine might have an effect on defecation. Immune checkpoint suppressor-related toxicity of the digestive tract is usually manifested as constipation, which may include diarrhea, abdominal pain, mucus or blood in the stool, change in stool habits (compared to before, increase/decrease in the number of defecation, different defecation time, prolonged or shortened defecation time, etc.), fever, and other symptoms. In severe cases, it can also lead to intestinal Perforation or even death. Different immune checkpoint inhibition drugs had different rates of developing digestive toxicity. The rate of diarrhea after treatment with CTLA - 4 inhibition drugs (27% - 31%) was higher than that of the treatment with PD-L1/PD-L1 inhibition drugs (less than 4%). According to the number of defecations, it was divided into mild (less than 4 times), moderate (4 - 6 times), and severe (more than 6 times). Under normal circumstances, it was mild diarrhea, but other digestive tract complications such as inflammation and colonic ulcers needed to be vigilant. In addition, at present, immune checkpoint suppressors are often combined with radiation therapy, chemotherapy drugs, targeted therapy drugs, etc. These measures involved in the combination therapy may also lead to corresponding adverse reactions in the digestive tract. For example, chemotherapy, chemotherapy, targeted therapy drugs all have adverse effects that cause diarrhea, and infection during diagnosis and treatment can also cause diarrhea. Read more exciting novels for free

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