Well, without having read the 'Nito Lazy Foreign World Syndrome' light novel, we can only speculate. It could be that the protagonist, due to some syndrome or condition, has a different perspective when in the foreign world. This might lead to a story that subverts typical isekai tropes. For example, instead of immediately striving for power or glory, the lazy nature might make the character focus on more personal and simple pleasures in the new world, which in turn could attract different types of allies or enemies. There could also be a mystery or quest related to curing or understanding this 'syndrome' within the context of the foreign world.
I'm not familiar with the exact plot of this light novel. But generally, light novels in the 'isekai' (transported to another world) genre often involve a protagonist being sent to a different world and facing various challenges, adventures, and making new relationships.
Since I don't know the details of 'Nito Lazy Foreign World Syndrome' specifically, in most such light novels, the protagonist might gain some special abilities in the foreign world. There could be elements of exploring the new world, dealing with different races, magic systems, and political situations. Maybe in this one, the 'lazy' aspect implies a unique take on how the protagonist approaches these challenges, perhaps using unorthodox or laid - back methods.
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