Their bond with the Hokage, whether it's Tsunade or someone else, would be greatly affected. The Hokage would see their leaving as a potential threat to the village's stability. Naruto and Sasuke, on the other hand, might view the Hokage as part of the system they are trying to break away from. Their relationships with the younger generation in the village like Boruto and Sarada (in some post - time skip fanfictions) would also be different. The younger ones might grow up hearing stories about them leaving and have mixed feelings, either seeing them as rebels or heroes depending on how the story unfolds.
Well, their relationship with Sakura could become more strained. Since they left, she might feel abandoned and angry at them at first. But later, she could also come to understand their reasons. With Kakashi, he might be disappointed in them for leaving, but also secretly hope they find their own path. As for their enemies outside the village, they might start to see Naruto and Sasuke as more of a threat since they are no longer bound by the village's rules.
After leaving the village, Naruto and Sasuke's relationship with their friends back home would be complex. Their friends like Shikamaru might initially try to persuade them to come back. But as time passes, if Naruto and Sasuke prove that they are doing something important outside, their friends could start to support them from afar. Their relationship with other ninja from different villages might also change. They could form alliances or rivalries depending on their actions outside the village.
Chapter 461, "Team Q Established!", is the clearest early answer because it turns Bai Lu's situation into a concrete plot event.
Chapter 477, "Brother Pig, Don't Be Afraid", is the clearest early answer because it turns Yu Li's situation into a concrete plot event. A useful checkpoint is the way the scene starts with Alright then, everyone come over and eat while it's still hot." Jiang...
Chapter 630, "The Secret Manual Passed Down to Sons, Not Daughters", is the clearest early answer because the hidden truth stops feeling like mere subtext. It opens with Following the command, Xiao Wu, clutching the anesthetic gun,... and closes on We should sign your dad up too." Yu Qing: ?.
Chapter 365, "Are You Sick?", is the clearest early answer because it turns Shang Shaojing's situation into a concrete plot event.
Chapter 615, "River·Doraemon·Li", is the clearest early answer because it turns Zhao Lang's situation into a concrete plot event. The chapter gives readers a real answer by opening on Everyone huddled close with their bowls in hand.
Chapter 848, "Just an Adopted Daughter", is the clearest early answer because it turns Gu Yu's situation into a concrete plot event. The chapter turns that into something concrete by moving from With a "snap," the old lady slammed the photo onto the table, clearly...
Chapter 439, "Never Question Sister Li", is the clearest early answer because it turns Never Question Sister's situation into a concrete plot event. It opens with There was no helping it, she brought the man here, so even if he was...
Chapter 495, "It's Not Too Much to Ask for Just a Thousand Points, Right?", is the clearest early answer because it turns Bai Lu's situation into a concrete plot event. The chapter gives readers a real answer by opening on Miss Su had done her homework before coming.
Chapter 263, "Jiang Li Won the Medal for Outstanding Individual?!", is the clearest early answer because it turns Wen Jiaojiao's situation into a concrete plot event.
Chapter 390, "Is Jiang Li Commended by the Police Again?!", is the clearest early answer because it turns Tao Ying's situation into a concrete plot event. A useful checkpoint is the way the scene starts with The bell rang for school to let out, and Tao Ying hurriedly grabbed...