One possibility is that Jerma had a dream that he was unable to achieve. He may have dedicated a large part of his life to this dream, like becoming a professional athlete. But due to an injury or some other unforeseen circumstances, he had to give up on that dream. This would be a deeply sad and disheartening experience, making him question his purpose and leaving him with a sense of loss and disappointment.
Perhaps Jerma was betrayed by a close acquaintance. This person could have spread false rumors about Jerma or stolen something important from him, causing great distress and sadness. For instance, if this acquaintance was a business partner and they embezzled money, leaving Jerma in a difficult financial and emotional state.
A practical answer is Chapter 22, because it turns the idea into a concrete scene. The chapter opens with Hearing this, Su Yinwan looked at Shang Shaojing with a face full of..., adds pressure through Why are you yelling so loudly?, and ends on Jiang Li's righteousness temporarily shut Jiang Yan.
If you want the clearest chapter reference, go to Chapter 11. Early on, After a meeting, Shang Shaojing pinched the bridge of his nose, tired, and...; later, the chapter leans on How is it going with the Jiang Family?" The assistant looked troubled and....
If you want the clearest chapter reference, go to Chapter 23. Early on, Although Jiang Li exerted very little strength, Jiang Yan instantly felt...; later, the chapter leans on The pain twisted his face grotesquely as he dove headfirst into the sofa..
Chapter 25 is the strongest chapter-level answer because it starts from Therefore, from his childhood, Jiang Shixu had felt an extreme aversion to... and follows through on Having worked beside Shen Lan for over a decade, she had been there when....
The best chapter pointer here is Chapter 68, "She finally managed to win a round back!". It opens with Jiang Li carried the noodles straight out of the kitchen and came to the... and closes on But didn't Uncle Zhao say he was still sick?.
The best chapter pointer here is Chapter 61, "Young Master Before vs After Going to the Countryside". It opens with Hahahaha, oh my god, Jiang Li's mouth is even more venomous. and closes on A cold shower is pretty normal, right?.
The best chapter pointer here is Chapter 49, "Mysticism Girl Jiang Li". It opens with My phone!!!" Jiang Yan's roar echoed continuously through the mountains in... and closes on Thinking this, Jiang Yan marched forward, pulled Jiang Li down from her....
Chapter 16 is the strongest chapter-level answer because it starts from Just as the words fell, Jiang Shixu swiftly cast his eyes downward. and follows through on Jiang Shixu panicked, set down the bowl, and reached forward to grab her....
The best chapter pointer here is Chapter 25, "He's Actually Mr. Shen's Son?!". It opens with Therefore, from his childhood, Jiang Shixu had felt an extreme aversion to... and closes on Having worked beside Shen Lan for over a decade, she had been there when....
The best chapter pointer here is Chapter 24, "The Cause of Jiang Shixu's Illness". It opens with Not only that, even the non-mainstream photos she had previously posted on... and closes on Shi Xu rarely feels like going out, so that's nice." Aware that he....