Granny Seal'e revered Negary.
That was undeniable, but her reverence and her pursuit of ideals did not conflict against one another.
It was because she understood Negary's power that she paid close attention to him, even dispatching the Dazzled and the Chopped Hand to attack him and successfully deprive one of Negary's trump cards, the Church of the Divine Grace's original Evil Spirit.
If not for that, with the power of the original Evil Spirit, it might have been possible for him to break out of the restraints of her destiny power.
Destiny was the ability that Granny Seal'e obtained through releasing the first stage of her [Origin], its strength in direct combat was negligible and required extensive layers of preparations in order to exert its greatest effect.
And her preparations up to this point had made it so that not even Nala who had obtained the authority of the 3 Gods could resist this power.