Chapter: 12 Experiments

Next, Lu Li had a very comfortable life.

The senior brothers and sisters in the laboratory are very enthusiastic. If he has any questions, the senior brothers and sisters will take the initiative to help, and the relationship between him and these senior brothers and sisters is also very harmonious.

When not in the laboratory, Lu Li usually plays around the school with Qin Wei's senior sister. However, he has not confirmed the relationship with Qin Wei. It is better to make progress gradually.

At the same time, he also took the time to register related patents for single-base gene editing technology. This technology is not a black technology that transcends the times. You must register a patent first to better protect your own interests.

On this day, eight o'clock in the evening.

In the laboratory.

"School brother Lu, see you tomorrow."

A senior took off his scientific research uniform and said goodbye to Lu Li.

"See you tomorrow."

Lu Li smiled and continued to observe the cells in the petri dish with a micromanipulation instrument.

He is experimenting with single-base gene editing technology.

The experimental material is the blood of a cancer patient.

He will extract the immune cells from the blood sample, and then use single-base gene editing technology to inactivate the gene that encodes the PD-1 protein in the immune cells.

PD-1 is also called the programmed death receptor on the surface of immune cells. Once it binds to the ligand PD-L1 on cancer cells, it will block the killing of cancer cells by immune cells.

If this experiment is successful, only need to inject the gene-edited cells into the patient's body, which can enhance the lethality of the patient's immune cells against cancer cells and benefit cancer patients.

"It is too much trouble to do these experiments in the laboratory."

Lu Li sighed softly.

Through the cell editor, he can perfectly control his own cells and perform atomic-level operations on any substance in the cell. As for modifying genes, it is not too simple.

However, experimenting with these instruments in the laboratory is a lot of trouble. Existing instruments cannot accurately manipulate genes. Special methods must be used. The single-base gene editing technology he constructed is one of the methods.

"Hey, I can't say that the current instrument is too backward, mainly because my plug-in is too strong."

Lu Li smiled again and continued the experiment.

After a whole night of research, the sky soon brightened.

Professor Xu walked in, wearing a scientific research suit, and seeing Lu Li, he said with some concern: "You didn't rest last night and have been doing experiments?"

"When the experiment has reached a critical stage, I need to keep an eye on it. Fortunately, the experiment was very successful."

Lu Li smiled brightly, picked up an experimental data report, and handed it to Professor Xu, "I used single-base gene editing technology to successfully inactivate the gene encoding the PD-1 protein in immune cells, and it was off-target. Low, only 1.3%."

The so-called off-target refers to editing other genes.

For example, if you want to edit the A gene, you end up editing the B gene.

This is a serious security risk.

The current mainstream CRISPR-Cas9 gene editing technology has high off-target. This is also an important reason why CRISPR-Cas9 gene editing technology cannot be commercialized.

"Let me take a look!"

Professor Xu excitedly accepted the document handed over by Lu Li and looked at it. The more he looked at it, the happier he was, and a bright smile gradually appeared on his face.

"Sure enough, the single-base gene editing technology you invented is at least ten times more advanced than CRISPR-Cas9 gene editing technology. With this technology, the field of gene editing technology is about to enter a new era. However, these The data is not enough. You can do a few more experiments and collect some data, and then you can write a paper. After finishing writing, I will help you to read it and vote for "Cell"."

Professor Xu said with excitement.

Lu Li nodded and did not care about taking a break. He ate something in a hurry and continued the experiment until the afternoon, completing four more experiments and recording the experimental data.

"Perfect!"

Professor Xu has been observing and guiding him. Seeing these data, he suddenly slapped his thigh and let out a cry of excitement. He once again felt that accepting Lu Li as a student might be the most proud thing in his life. This student is simply too genius!

"F*ck, awesome!"

"Lu Xuedi, from now on, you will be my idol!"

"From these experimental data, single-base gene editing technology is more advanced than CRISPR-Cas9 gene editing technology in all aspects, and can completely replace CRISPR-Cas9 gene editing technology! My God! There is a big earthquake in the biological world! "

"Xuedi Lu will be my boasting capital from now on."

Other people have been observing from the side as well. At this time, they couldn't help cheering. The eyes that looked at Lu Li were full of envy and admiration, as if they saw a great scientist rising up.

As for jealousy, it does not exist. When the gap is small, jealousy will occur. When the gap is large to a certain extent, only look up and worship! *