Most curses had to be tethered onto something, whether that something be tangible or intangible.
Of course, for a being like the Creator who stand on the highest peak of power that touch upon the Source of Everything, he could simply create a curse out of nowhere and did not tether it to anything
But from what Odin knows of the Creator, he would not disturb the balance of order of the Omniverse.
This is because from what Odin knows of the lore about the Creator and the Destroyer, it was that before the Creator had a personality, had an avatar, had feelings, in the beginning he was like those winged creatures that the Supreme One had created in the past.
They were more like an independent artificial intelligence but with clear directive.
One of that is not to disturb the natural order.