Rayden smiled upon hearing the question from Doctor Lu. From this question alone, and the facial expression he has while asking Rayden could already infer a few things.
One is that they might know something about Xi Ana's condition, as for how deep not knowledge is he cannot tell and second is that one way or another they truly care of Xi Ana and as a friend, won't that make him happy?
As Xi Ana's personal psychiatrist of course he knew about her trauma and the recurring nightmares she always have. Even her long time insomnia is something he is very much aware of.
Xi Ana has always been the type of person who doesn't easily open up to others, if it wasn't because they were friends and An Qi Lu's support she wouldn't have thought of seeing a doctor. Since Lu Nai He is also a doctor, he must have found out about Xi Ana's intake of sleeping pills.
Going back to his question, he really can't answer it since everything about doctor's patient is confidential.