Great civilizations had risen and fallen in the Americas before the arrival of the Europeans. In North America, the complex Pueblo societies including the Mogollon, Hohokam, and Anasazi as well as the

One effect of the Crusades was that a larger portion of western Europe became familiar with the goods of the East. A lively trade subsequently developed along a variety of routes known collectively as the Silk Road to supply the demand for these products. Brigands and greedy middlemen made the trip along this route expensive and dangerous. By 1492, Europe—recovered from the Black Death and in search of new products and new wealth—was anxious to improve trade and communications with the rest of the world. Venice and Genoa led the way in trading with the East. The lure of profit pushed explorers to seek new trade routes to the Spice Islands and eliminate Muslim middlemen.

Portugal, under the leadership of Prince Henry the Navigator, attempted to send ships around the continent of Africa. Ferdinand of Aragon and Isabella of Castile hired Columbus to find a route to the East by going west. As strong supporters of the Catholic Church, they sought to bring Christianity to the East and any newly found lands, as well as hoping to find sources of wealth.