A Surprise Attack
Ten years ago, Dante's incident caused a major change in the world. I think that was where the world truly began to change; gradually, all nations began to develop in terms of strength, not just technologically, but in pure combat capability. I would say that was the epicenter of change, but contrary to what everyone thinks, it was actually much worse than just a common change.
With Dante Scarlet's death, the incident took two paths that changed the world. First, the sealing of the two women who could match the rulers. With this sealing, the status of witches did not diminish; on the contrary, the balance and status quo among all others became precarious.