A villain like Shigaraki would likely be interested in the power levels in the MCU fanfiction. He's always looking for ways to increase his own power, and seeing the various powerful artifacts and abilities in the MCU might give him some ideas. He could think about how he could use similar things in his own plans to take over the MHA world.
Another theme could be the clash of different universes. Amazo is from the DC universe and Saitama is from One Punch Man. Fanfics might play around with how these two different universes' rules and powers interact when these two characters meet. Also, there could be themes related to respect and rivalry. Saitama is often very nonchalant about his power, while Amazo is a complex android with various abilities. How they view each other in the fanfic can create interesting storylines.
Tornado of Terror would likely be one of the first to try and take on Evil Saitama. She's powerful and confident, but she would soon realize the extent of his power. Mumen Rider, despite being weak, would still stand up to Evil Saitama out of a sense of justice. He would be quickly defeated but his act of courage might inspire other heroes to step up.
Some MHA characters might be flattered. For example, Midoriya would probably be really excited and take it as a sign of how much he's inspired people. He might even look for positive lessons in the fanfiction to improve himself.
If the MHA characters were to react to a Mastermind fanfiction, some would be more accepting than others. Characters like Ochaco might find it really exciting. She's a fan of the heroes herself, so seeing different takes in fanfiction would be like getting a new perspective on the MHA world. However, characters like Shoto, who are more reserved, might be a bit hesitant. He might need some time to process what he's reading. But overall, it would be a very interesting scenario as it would show how the characters view different interpretations of their world.
Some characters would be shocked. For example, if the fanfiction had a really dark and unexpected Mastermind plot, like a hero turning out to be the mastermind of all the villains' plans, characters like Tsuyu would be very taken aback. She'd probably question the motives behind such a plot. Then there are characters like Denki. He might be more into it if it had some cool action scenes in the fanfiction, regardless of how out - of - the - blue the Mastermind storyline was. And Nejire would probably be super curious about the emotional depth of the characters in the fanfiction.
Saitama would win. He has shown incredible strength with just one punch. His power seems limitless, and in a fanfiction scenario, his simplicity and raw power would likely overpower Jiren's more complex abilities.
One possible plot twist could be that Jiren discovers a way to nullify Saitama's strength. Maybe he finds some sort of energy - draining technique that weakens Saitama over time. Another could be that Saitama holds back for some reason, like he wants to see the full extent of Jiren's power, and in doing so, he gets into a real struggle.
Saitama's overpowered strength would likely be a huge disruptor in the MHA world. His simple yet extreme power of being able to defeat any enemy with one punch would make him a top - tier hero instantly. Genos, with his advanced cybernetic enhancements, would also be quite formidable. He could potentially be part of the development of new support items or hero gear in the MHA universe, given his knowledge of technology. And his combat abilities would put him in the ranks of the stronger heroes there.
Saitama's overpowered nature would completely disrupt the power balance in the MHA universe. His simple yet extreme strength and speed would make him an outlier. For example, in MHA, most heroes have to strategize and work in teams against villains. But Saitama could just one - punch most threats away. This would change the way villains operate as well, perhaps making them more desperate or more likely to target Saitama directly. It could also lead to interesting scenarios where heroes might be both in awe and a bit intimidated by his presence.