The Bnha universe's reaction would be mixed. Those who are into complex stories, like Todoroki, might study the relationships in Hamilton fanfiction. But others, like Mineta, might not be interested at all because it doesn't have much to do with his usual interests. Overall, it would depend on the individual characters' personalities and interests.
Some would be inspired. Characters like All Might might see Peter Parker's journey as similar to his own in some ways. Both are trying to do good in a world full of challenges. All Might could appreciate Peter's determination to protect his city despite having a normal life outside of being a hero.
For heroic - centric fanfictions, they would likely be disdainful. Since they oppose heroes, seeing stories that glorify heroes would annoy them. They might scoff at the idealized versions of heroes in those fanfictions.
Toge Inumaki is important too. His special cursed speech ability makes him stand out. Also, the principal of the school, Masamichi Yaga, is likely to be important as he is in a position of authority and has an influence on Gojo and the other students. There could be other characters like the members of different clans that also play roles in the complex web of the story.