Deadpool became Deadpool through a series of complex and sometimes convoluted events in the comics. He was originally a mercenary named Wade Wilson, who underwent experimental treatments that gave him his unique powers and personality.
The change in its appearance can make it scary. For example, if its usually cute yellow fur turns dark or if its bright red cheeks become a sinister red glow. Also, if it starts to behave in an uncharacteristic way, like making menacing noises instead of its usual cute sounds.
There is a loose link. The version of Deadpool in Wolverine Origins provided a starting point, but the standalone Deadpool movies developed his character and story in a more distinct and expanded way, deviating from the initial portrayal to create a more focused and engaging narrative.
It's a bit of a mixed bag. While there's a link, the portrayal of Deadpool in Wolverine Origins doesn't fully align with his later, more developed storyline. Some elements were changed or not fully explored.
Obviously, the main characters are usually Pikachu. But sometimes, there could be other Pokémon that play important supporting roles. For instance, a Pichu could be a sidekick or a younger Pokémon that the Pikachus are protecting.
One interesting plot could be two Pikachus from different regions meeting and learning about each other's unique electric attacks. For example, one Pikachu might know a special move that the other has never seen before. They could then teach each other and become stronger together.