I'm not entirely sure as I haven't read it in detail. But generally, it might be about some sort of fantasy story involving a bishoujo (a cute girl character in Japanese media) and an ojisan (uncle or older man) in a novel - like setting.
One popular 'isekai ojisan light novel' could be 'Isekai Ojisan: Isekai ni Tensei Shita Kedo Cheat Nanka Shinai yo'. It tells an interesting story about an uncle who gets isekai -ed but doesn't have the typical cheat skills.
I'm not sure who the main characters are exactly as I don't know this work well. But from the title, it seems that a bishoujo and an ojisan would be important characters.
The term 'frozen sexy hot cartoon' could imply cartoons that have a combination of icy or cold settings along with sexually appealing characters. These could have visually stunning graphics and narratives that play on contrasts between cold and hot elements. But it's important to note that such concepts can be subjective and interpreted differently by different viewers.
AI-generated sexy comics usually show a level of precision and consistency in the art style. Sometimes, they might push the boundaries of conventional depictions for shock value.
Well, to depict biology in cartoons, you could start with basic concepts. Maybe show the life cycle of a plant, from seed to full-grown. Or illustrate how different animals adapt to their environments. Use bright colors and fun shapes to make it engaging.