Muzan was ultimately defeated by the collective efforts of Tanjiro, Nezuko, and the other demon slayers. Their teamwork and perseverance were key to ending Muzan's reign of terror in the manga.
Well, muzan x reader fanfiction often explores a very interesting relationship. In such fanfictions, the writer usually dives deep into the dynamic between muzan, who is a complex and often dark character, and the reader - insert, which can be a very exciting exploration of power, mystery, and sometimes a touch of romance. It allows fans to put themselves in a fictional world with muzan and experience different scenarios.
A simple Nezuko and Zenitsu fanfiction could be that they go on a journey together. Along the way, they encounter other demon slayers who are initially skeptical of Nezuko. But Zenitsu stands up for her, explaining that she's different. This shows the depth of their friendship and how Zenitsu has come to trust Nezuko completely.