Well, Negan's end in the comics isn't straightforwardly due to one specific killing act. It's more complicated and involves multiple factors and characters' actions.
The wizarding community would be shocked. Guns are not part of their world, and for Harry to use one to kill Voldemort would be unthinkable for many. There would be outrage from some traditional wizards who believe in magic as the only proper way to fight.
Most of the fandom would probably be horrified. Naruto is known for his positive values, and killing a family member is completely against that. There would likely be a lot of criticism towards the author of such a fanfic.
Well, Negan first appears in the series as a major antagonist. He has a very distinct personality. He's confident, often to the point of being cocky. His group, the Saviors, would extort other communities for resources. He uses fear as a tool to control those around him. His actions have a huge impact on the other characters in the show, like Rick and his group.