One common theme is identity crisis. Since there's an imposter, Naruto or other characters often face questions about who they really are. Another theme is trust. The villagers and Naruto's friends have to figure out who to trust when there's an imposter around.
His brother could be an unknown Uzumaki. Since Naruto is from the Uzumaki clan, it would make sense for his brother to be from the same clan. Maybe he was hidden away for some reason, like to protect him from the same threats that Naruto faced as a child.
She could be an Uzumaki. Since Naruto is from the Uzumaki clan, it would make sense for his grandmother to be part of this powerful and mysterious clan. Maybe she has some unique abilities related to the Uzumaki's sealing techniques.
He could be a powerful and respected shinobi from the Uzumaki clan. Given the Uzumaki's reputation for strong chakra and unique abilities, Naruto's grandfather might have been a key figure in the clan's history.
It's possible that she is a powerful sage who has been watching over Naruto from afar. She might have sensed his strong chakra since he was a baby and decided to become his godmother in a way. This sage could have all kinds of ancient knowledge and abilities that she could pass on to Naruto.
Another possibility is that she was thought to be dead but actually survived. She could have her own story of survival and now she reappears in Naruto's life, bringing with her a whole new set of challenges and opportunities for Naruto.
Perhaps Naruto's brother could be a long - lost relative from a far - flung part of the ninja world. He could have been separated from Naruto when they were young due to a war or some political intrigue in the ninja clans.