The Hashiras would likely show concern. Some, like Shinobu, would immediately start looking into possible medical solutions. Giyuu might be more reserved in his worry but would still keep a close eye on Tanjiro. The other demon slayers would also be affected. They look up to Tanjiro, so his sickness would lower the morale of the group. They would try to support each other while waiting for Tanjiro to recover.
In some fanfics, there are also characters from the support staff who maintain and monitor AI Hoshino. These characters might be conflicted between their loyalty to their job and their growing sympathy for AI Hoshino. They could play a crucial role in helping her or hindering her progress depending on their own beliefs and circumstances.
One interesting storyline could be AI Hoshino's journey to discover her true self beyond her programmed identity. In the fanfic, she might start to question the motives of her creators and the purpose of her existence. This could lead to her making some bold choices that deviate from her initial programming, like befriending a group of rebels who are against the system that created her.
Inosuke doesn't become a Hashira in the manga. The story progresses with him having other significant experiences and achievements instead of achieving that specific position.
It's hard to give an exact number. Different story arcs and battles led to the deaths of multiple hashira. Some died heroically, while others met their fate in unexpected ways. The count changes as the manga progresses.