The Hashiras would likely show concern. Some, like Shinobu, would immediately start looking into possible medical solutions. Giyuu might be more reserved in his worry but would still keep a close eye on Tanjiro. The other demon slayers would also be affected. They look up to Tanjiro, so his sickness would lower the morale of the group. They would try to support each other while waiting for Tanjiro to recover.
It gives fans a chance to explore different 'what - if' scenarios. By seeing the Avengers' reactions, fans can get a deeper understanding of the characters.
Some fans might be disappointed. Fanfiction often allows them to explore different scenarios with Naruto's character. If he gives it up, it's like closing a door on those creative possibilities.
The Naruto fandom would likely be very divided. Some fans would be extremely outraged as it goes against the core values and character of Naruto. They might condemn such a fanfiction.
On the other hand, there would be fans who would welcome it. Maybe they never liked the pairing in the first place or they think it adds an interesting twist to the story. They could start exploring new relationships for both Sasuke and Sakura in their own fan - created stories.
The Naruto fandom would probably react very negatively. Fans are used to seeing Naruto as a hero, a symbol of hope and growth. A fanfic that portrays him as a slave goes against the very essence of what Naruto represents. There would be a lot of criticism on social media platforms, and many fans might even call for the fanfic to be removed or boycotted.
Tanjiro might use his sense of smell to detect hidden threats. Since his sense of smell is super - enhanced, he could sniff out any demons or traps in the way of saving Rengoku. For example, if there are demons disguised as allies, Tanjiro would be able to tell by their scent.