Madara Uchiha could be the cause. Even if he's dead, his influence could still be around. Maybe he left behind some sort of genjutsu or curse that affects Naruto's mind and drives him crazy. After all, Madara was always planning something big and Naruto would be a great pawn if he's out of control.
In a 'naruto goes crazy fanfic', Naruto might start to use his powers in unpredictable and extreme ways. He could go against his usual moral code and attack his friends or allies by mistake, perhaps due to some powerful dark influence or a misunderstanding of a new jutsu he's acquired.
In some fanfictions like this, Harry Potter could go crazy because of a powerful dark magic curse. This curse might make him see his friends as enemies and vice versa. He could then start a series of chaotic events at Hogwarts, like trying to attack his best friends. Another idea is that Harry discovers a new type of magic that is so different from what he knows that it drives him to the brink of madness as he tries to understand and master it.
Well, one possibility could be that drunk Harry starts casting random spells all over Hogwarts. He might accidentally turn the Great Hall into a giant ice rink or make the portraits start singing opera. Another idea is that he thinks he's on a wild adventure and tries to 'fight' imaginary enemies, causing chaos in the corridors.
Obviously, Harry Potter himself would be the central character as the title implies. Hermione and Ron would most likely be involved as well, since they are Harry's closest friends. They would probably be the ones trying to figure out what's wrong with Harry and how to fix him. Dumbledore could also play a big role, as he often has the wisdom and power to deal with strange situations.
I'm not entirely sure as the description is rather unclear. It could potentially be about a character named Issei in the 'DxD' universe and some sort of action related to a fanfiction about him. Maybe it's about exploring or creating a fan - made story where Issei is involved in a stroking action, though without more context it's hard to be specific.
It could be his fellow team members. They might betray him out of greed for power. Maybe they thought that by getting rid of Issei, they could gain more resources or a higher position within their group.
Issei could react with anger. He might lash out at his partner and the person they cheated with. He could also become very confrontational, demanding explanations and apologies.