Well, it really depends on how the fanfic is written. If the fanfic focuses on Naruto's weaknesses and Danzo's preparedness, Danzo could potentially win. He has a lot of political power and experience. However, if it follows the general power scale of the Naruto universe, Naruto has a better chance. His positive energy and the power of friendship (a bit cheesy but true in Naruto's world) often help him overcome his opponents. Naruto also has the ability to quickly adapt to new situations, which would be a big plus against Danzo.
One possible plot twist could be that Danzo is actually being controlled by an even greater enemy. So, when Naruto is about to defeat him, he realizes that there's a bigger threat behind Danzo. Another could be that Danzo reveals a hidden power that he has been suppressing all along and suddenly becomes much stronger than Naruto expected.
He'll likely lose his power and influence in the village. Once Naruto reveals his secrets, the villagers won't trust him anymore. His actions might be put on trial, and he could be exiled from the village.
One possible motive could be to gain control over Naruto's power. Since Naruto has the Nine - Tails within him, Danzo might want to use that power for his own political or military gains. He's always been power - hungry and sees Naruto as a tool to achieve his goals of making Konoha stronger in his own way, which might involve more underhanded and controlling methods.
It could also be a completely new character introduced into the fanfiction. A foreign ninja who was inspired by some of Danzo's ideas (not the bad ones) and comes to Konoha to take on the role of successor, bringing in new perspectives and ways of doing things.
One possible motive could be revenge. Maybe the oc or someone close to the oc has been wronged by Danzo in the past. So, to seek justice, the oc decides to take him down.
It could also be due to Naruto's outcast status in the village initially. Danzo might think that banishing Naruto would be an easy decision as Naruto doesn't have many supporters at first. He might believe that by getting rid of Naruto, he can maintain the status quo in the village and prevent any disruptions that Naruto's presence might cause in the future.
One aspect of Hanzo x Widowmaker fanfiction could be the exploration of their contrasting personalities. Hanzo is often portrayed as a brooding and honor - bound character, while Widowmaker is cold and efficient. In fanfictions, their relationship might start from an unexpected encounter on the battlefield. For example, they could be forced to team up against a common enemy, which then leads to a growing understanding and attraction between them.