I think young Sasuke would have a very intense reaction. He was so consumed by his hatred for Itachi at that young age. A Sasuke vs Itachi fanfiction would be like a trigger for him. He would be eager to see how the fictional fight is portrayed. If Sasuke in the fanfiction is shown as strong, it might fuel his own ego and make him strive even harder to become powerful. However, if the fanfiction shows Itachi as superior, it could enrage him. He might feel that it undermines his own goal of defeating Itachi and he might even want to find the writer to correct their 'wrong' view.
Nezuko is initially 12 years old in the manga. As the story unfolds, her age doesn't change significantly in a traditional sense, but her character development is quite remarkable.