Naruto would be devastated. He might blame himself for not being able to protect his son. Sasuke would be angry and would likely go on a hunt for the perpetrator. His friends like Sarada and Mitsuki would be heartbroken. Sarada might vow to become stronger to prevent such a tragedy from happening again.
Boruto's reaction would be complex. He'd be heartbroken, for sure. He might start to question his own worth and purpose. But over time, he'd realize that he has to carry on Naruto's legacy. He'd become more serious and focused. He'd also become more empathetic towards others, understanding the weight of sacrifice. He might even start to study Naruto's techniques and leadership style more closely, trying to emulate the things that made Naruto such a great Hokage and hero.
Well, Naruto would be in a really tough spot. He loves his family and the village, and this situation would be a huge blow to his traditional values. He might struggle to understand how this happened between his son and Hinata. Hinata's family, on the other hand, would be protective of her. Her father would want to ensure that Boruto is taking responsibility. Boruto's friends would also be surprised. Some might be supportive, like Shikadai, who would try to see the good in the situation, while others might distance themselves at first, not sure how to handle this new and rather strange development.
In such a fanfiction, Sarada might be in awe of Itachi. She could learn valuable ninja skills from him. Itachi might see Sarada's potential and offer her some advice on how to better control her Sharingan and improve her combat abilities.
Itachi would probably be very calm and composed. He might see Sarada as a symbol of the new generation of ninjas in the village. He could be gentle with her, perhaps sensing her potential and her desire to grow as a ninja.
A possible relationship could be one of mutual respect. Sarada would respect Itachi for his skills and his past sacrifices. Itachi, on the other hand, might see Sarada as a symbol of hope for the future of the Uchiha clan. They could share stories about the Uchiha, with Itachi passing on the history and traditions that Sarada might not be fully aware of. This could strengthen their bond and lead to a deeper understanding between them. In the fanfiction, they might also team up to face a common enemy, relying on each other's strengths and abilities, which would further solidify their relationship.
Well, Boruto could be very inspired. Naruto's past is full of struggles, from not having parents around to being constantly underestimated. When Boruto discovers this in the fanfiction, he might realize that his own problems are not as big as he thought. He could be motivated to work harder and not take for granted the things he has, seeing how much Naruto had to fight for everything.
Sakura would probably be initially terrified. She would try to use her medical ninjutsu skills to defend herself or at least slow Itachi down. If she realizes she can't overpower him physically, she might try to talk to him, asking him why he's doing this.
Some fans might like it. They could see it as a way to show Naruto's strict parenting side and how he is trying to instill good values in Boruto. It would add a new dimension to their relationship.