Sakura would be heartbroken. She'd likely spend hours upon hours by Naruto's side, trying to jog his memory with stories of their adventures together. She might even get a bit overbearing in her attempts. Sasuke, who has his own complex relationship with Naruto, would be conflicted. He'd see Naruto's forgetfulness as a sign of weakness at first but then realize the importance of their bond. Kakashi, being the experienced leader, would start by observing Naruto carefully to see exactly how much he has forgotten and then start a systematic process of helping him remember.
Sasuke would likely be devastated. Despite their past differences, Naruto was his rival and in a way, his closest friend. He might go into a deep state of regret and isolation. Sakura would be heart - broken. She loved Naruto, and his death would be a huge blow to her. She might become more withdrawn and focus all her energy on her medical ninjutsu. Kakashi would be filled with a sense of failure. He was Naruto's teacher, and he would feel responsible for not being able to protect him.
Sasuke might initially be indifferent on the surface, but deep down he would feel a sense of loss. He has always had a rivalry with Naruto, and Naruto's departure would mean an end to that dynamic. Sakura would be devastated. She has grown to care about Naruto as a friend and teammate, and his leaving would leave a big hole in the team.
Toge Inumaki is important too. His special cursed speech ability makes him stand out. Also, the principal of the school, Masamichi Yaga, is likely to be important as he is in a position of authority and has an influence on Gojo and the other students. There could be other characters like the members of different clans that also play roles in the complex web of the story.
Well, Sasuke might initially be a bit shocked but then he'd try to hide his concern. Sakura would be very empathetic and might immediately want to do something to help Naruto. Kakashi, being the experienced one, would take a more calm and strategic approach to deal with Naruto's situation and protect him from further abuse.
They would be shocked at first. Minato would be filled with pride and joy seeing his son all grown up. Kakashi would respect Naruto's strength. Obito might be a bit envious of Naruto's popularity but also admire his spirit. Rin would be very friendly towards Naruto.