It's possible. Sometimes these kinds of stories draw from real-life incidents but might be embellished or changed to make them more engaging for the audience.
As I don't know the specific 'a murder to remember real story', I can't say for sure what the main characters are. But generally in a murder story, there would be the victim, the murderer, and probably some witnesses or investigators.
I'm not sure specifically which 'a murder to remember' real story you are referring to. There could be many real - life murder cases that might be given such a title. It could be a local case or one that got a lot of media attention in a particular area.